IHC (Immunohiostchemistry)
(Immunohistochemistry of PAK2 in mouse spleen tissue with PAK2 antibody at 10 ug/mL.)
Rabbit PAK2 Polyclonal Antibody | anti-PAK2 antibody
PAK2 Antibody
Gene Names
PAK2; PAK65; PAKgamma
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
PAK2, Antibody; PAK2 Antibody; p21-activated kinase 2, PAK65; anti-PAK2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
524
Applicable Applications for anti-PAK2 antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a 14 amino acid peptide from near the carboxy terminus of human PAK2.
Target Name
PAK2
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IHC (Immunohiostchemistry)
(Immunohistochemistry of PAK2 in mouse spleen tissue with PAK2 antibody at 10 ug/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of PAK2 in mouse spleen tissue with PAK2 antibody at 10 ug/mL.)
WB (Western Blot)
(Western blot analysis of PAK2 in Jurkat lysate with PAK2 antibody at (A) 0.5 and (B) 1 ug/mL.)
WB (Western Blot)
(Western blot analysis of PAK2 in Jurkat lysate with PAK2 antibody at (A) 0.5 and (B) 1 ug/mL.)
Related Product Information for anti-PAK2 antibody
The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6, and are not activated by Cdc42/Rac binding. Of the six PAK proteins, only PAK2 is ubiquitously expressed and cleaved by caspase-3. This cleavage removes the amino-terminal regulatory domain and generates a constitutively active kinase fragment. Recent experiments have shown that following cleavage, the active fragment is myristoylated and directed to the plasma membrane and membrane ruffles where it promotes cell death via increased signaling through the c-Jun N-terminal kinase pathway, but without compromising mitochondrial integrity.
Product Categories/Family for anti-PAK2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
58,043 Da
NCBI Official Full Name
serine/threonine-protein kinase PAK 2
NCBI Official Synonym Full Names
p21 protein (Cdc42/Rac)-activated kinase 2
NCBI Official Symbol
PAK2
NCBI Official Synonym Symbols
PAK65; PAKgamma
NCBI Protein Information
serine/threonine-protein kinase PAK 2
UniProt Protein Name
Serine/threonine-protein kinase PAK 2
UniProt Gene Name
PAK2
UniProt Synonym Gene Names
PAK-2; p27; p34
UniProt Entry Name
PAK2_HUMAN
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Product Notes
The PAK2 pak2 (Catalog #AAA305194) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PAK2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PAK2 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the PAK2 pak2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PAK2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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