IHC (Immunohiostchemistry)
(Immunohistochemistry of PAK4 in human colon tissue with PAK4 antibody at 10 ug/mL.)
Rabbit anti-Human PAK4 Polyclonal Antibody | anti-PAK4 antibody
PAK4 Antibody
Reactivity
Human
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
PAK4, Antibody; PAK4 Antibody; p21-activated kinase 4; anti-PAK4 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
591
Applicable Applications for anti-PAK4 antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a 13 amino acid peptide from near the center of human PAK4.
Target Name
PAK4
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IHC (Immunohiostchemistry)
(Immunohistochemistry of PAK4 in human colon tissue with PAK4 antibody at 10 ug/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of PAK4 in human colon tissue with PAK4 antibody at 10 ug/mL.)
WB (Western Blot)
(Western blot analysis of PAK4 in SW480 lysate with PAK4 antibody at (A) 1 and (B) 2 ug/mL.)
WB (Western Blot)
(Western blot analysis of PAK4 in SW480 lysate with PAK4 antibody at (A) 1 and (B) 2 ug/mL.)
Related Product Information for anti-PAK4 antibody
The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK4 was initially identified as a novel effector of Cdc42Hs. Co-expression of PAK4 and Cdc42Hs resulted in induction of filopodia and actin polymerization, showing that it is involved in cytoskeletal reorganization. Other experiments have shown PAK4 to be essential for embryonic viability and proper neuronal development. PAK4 has also been implicated in anchorage-independent growth of tumor cells and is required for activation of several cancer prosurvival pathways.
Product Categories/Family for anti-PAK4 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
54,940 Da
NCBI Official Full Name
serine/threonine-protein kinase PAK 4 isoform 1
NCBI Official Synonym Full Names
p21 protein (Cdc42/Rac)-activated kinase 4
NCBI Official Symbol
PAK4
NCBI Protein Information
serine/threonine-protein kinase PAK 4
UniProt Protein Name
Serine/threonine-protein kinase PAK 4
UniProt Gene Name
PAK4
UniProt Synonym Gene Names
KIAA1142; PAK-4
UniProt Entry Name
PAK4_HUMAN
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Product Notes
The PAK4 pak4 (Catalog #AAA308188) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PAK4 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PAK4 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the PAK4 pak4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PAK4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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