IF (Immunofluorescence)
(Immunofluorescence of PARK2 in human brain tissue with PARK2 antibody at 20 μg/ml.)
Rabbit anti-Human PARK2 Polyclonal Antibody | anti-PARK2 antibody
PARK2 Antibody
Gene Names
PARK2; PDJ; PRKN; AR-JP; LPRS2
Reactivity
Human
Applications
Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
Purity
PARK2 antibody is affinity chromatography purified via peptide column.
Synonyms
PARK2, Antibody; PARK2 Antibody; PARK2; PDJ; PRKN; AR-JP; LPRS2; E3 ubiquitin-protein ligase parkin; Parkinson juvenile disease protein 2; Parkinson disease protein 2; parkin RBR E3 ubiquitin protein ligase; anti-PARK2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
PARK2 antibody is human specific.
Purity/Purification
PARK2 antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
465
Applicable Applications for anti-PARK2 antibody
IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
Conjugate
Unconjugated
Immunogen
PARK2 antibody was raised against a 17 amino acid peptide near the amino terminus of human PARK2
Buffer
PARK2 antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
PARK2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
IF (Immunofluorescence)
(Immunofluorescence of PARK2 in human brain tissue with PARK2 antibody at 20 μg/ml.)
IF (Immunofluorescence)
(Immunofluorescence of PARK2 in human brain tissue with PARK2 antibody at 20 μg/ml.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of PARK2 in human brain tissue with PARK2 antibody at 5 μg/ml.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of PARK2 in human brain tissue with PARK2 antibody at 5 μg/ml.)
WB (Western Blot)
(Western blot analysis of PARK2 in human cerebellum tissue lysate with PARK2 antibody at 1 μg/ml.)
WB (Western Blot)
(Western blot analysis of PARK2 in human cerebellum tissue lysate with PARK2 antibody at 1 μg/ml.)
Related Product Information for anti-PARK2 antibody
Parkinson's disease (PD) is a neurodegenerative disease whose symptoms include tremors, rigidity, bradykinesia, and postural instability (1). Mutations in the PARK2 gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease (2). The PARK2 protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation (3). Recent studies have suggested that PARK2 expression reduces the mitochondrial accumulation of the apoptosis protein Bax under basal conditions and directly ubiquitinates Bax, thereby promoting cell survival (4).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Predicted: 51 kDa
Observed: 55 kDa
Observed: 55 kDa
NCBI Official Full Name
E3 ubiquitin-protein ligase parkin isoform 1
NCBI Official Synonym Full Names
parkin RBR E3 ubiquitin protein ligase
NCBI Official Symbol
PARK2
NCBI Official Synonym Symbols
PDJ; PRKN; AR-JP; LPRS2
NCBI Protein Information
E3 ubiquitin-protein ligase parkin; parkinson juvenile disease protein 2; parkinson protein 2, E3 ubiquitin protein ligase (parkin); Parkinson disease (autosomal recessive, juvenile) 2, parkin
UniProt Protein Name
E3 ubiquitin-protein ligase parkin
UniProt Gene Name
PARK2
UniProt Synonym Gene Names
PRKN; Parkinson disease protein 2
UniProt Entry Name
PRKN2_HUMAN
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Product Notes
The PARK2 park2 (Catalog #AAA40767) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PARK2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PARK2 can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the PARK2 park2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PARK2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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