IF (Immunofluorescence)
(Immunofluorescence of PARL in 3T3 cells with PARL antibody at 2.50 μg/mL.)
Rabbit PARL Polyclonal Antibody | anti-PARL antibody
PARL Antibody
Gene Names
PARL; PSARL; PSARL1; RHBDS1; PRO2207; PSENIP2
Reactivity
Human, Mouse, Rat
Applications
Immunofluorescence, Immunocytochemistry, Western Blot, ELISA
Purity
PARL Antibody is affinity chromatography purified via peptide column.
Synonyms
PARL, Antibody; PARL Antibody; PARL; PSARL; PSARL1; RHBDS1; PRO2207; PSENIP2; Presenilins-associated rhomboid-like protein; mitochondrial; Mitochondrial intramembrane cleaving protease PARL; Pbeta; presenilin associated, rhomboid-like; anti-PARL antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
PARL Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
379
Applicable Applications for anti-PARL antibody
IF (Immunofluorescence), ICC (Immunocytochemistry), WB (Western Blot), ELISA
Conjugate
Unconjugated
Immunogen
PARL antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human PARL.
Buffer
PARL Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
Antibody can be stored at 4 degree C up to one year. Antibodies should not be exposed to prolonged high temperatures.
IF (Immunofluorescence)
(Immunofluorescence of PARL in 3T3 cells with PARL antibody at 2.50 μg/mL.)
IF (Immunofluorescence)
(Immunofluorescence of PARL in 3T3 cells with PARL antibody at 2.50 μg/mL.)
ICC (Immunocytochemistry)
(Immunocytochemistry of PARL in 3T3 cells with PARL antibody at 2.5 μg/mL.)
ICC (Immunocytochemistry)
(Immunocytochemistry of PARL in 3T3 cells with PARL antibody at 2.5 μg/mL.)
WB (Western Blot)
(Western blot analysis of PARL in 3T3 cell lysate with PARL antibody at (A) 1 and (B) 2 μg/mL.)
WB (Western Blot)
(Western blot analysis of PARL in 3T3 cell lysate with PARL antibody at (A) 1 and (B) 2 μg/mL.)
Related Product Information for anti-PARL antibody
PARL Antibody: PARL is a mitochondrial integral membrane protein and a member of the highly conserved rhomboid superfamily of membrane proteins. PARL is required for the control of apoptosis during postnatal growth and is required for the processing of OPA1, a protein that prevents the release of cytochrome C from the mitochondria in response to apoptotic signals. In lymphocytes and neurons, PARL's association with other proteins, such as the Bcl-2 family-related protein Hax1 and Omi can lead to the proteolytic processing of Omi by PARL, preventing the accumulation of Bax, thereby suppressing apoptosis. Variations in this gene have been associated with increased risk for type 2 diabetes. PARL may also play a role in the progression of Alzheimer's disease through its associations with presenilin-1 and -2. Multiple isoforms of PARL are known to exist.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
36,589 Da
NCBI Official Full Name
Presenilins-associated rhomboid-like protein, mitochondrial
NCBI Official Synonym Full Names
presenilin associated, rhomboid-like
NCBI Official Symbol
PARL
NCBI Official Synonym Symbols
PSARL; PSARL1; RHBDS1; PRO2207; PSENIP2
NCBI Protein Information
presenilins-associated rhomboid-like protein, mitochondrial; rhomboid 7 homolog 1; mitochondrial intramembrane cleaving protease PARL; mitochondrial intramembrane-cleaving protease PARL
UniProt Protein Name
Presenilins-associated rhomboid-like protein, mitochondrial
UniProt Gene Name
PARL
UniProt Synonym Gene Names
PSARL; Pbeta
UniProt Entry Name
PARL_HUMAN
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Product Notes
The PARL parl (Catalog #AAA39215) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PARL Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PARL can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), ICC (Immunocytochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the PARL parl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PARL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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