DB (Dot Blot)
(Dot blot analysis of mouse TSC2 Antibody (Phospho S1343) Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.)
Rabbit Phospho-mouse TSC2 (S1343) Polyclonal Antibody | anti-Tsc2 antibody
Phospho-mouse TSC2 (S1343) Antibody
Reactivity
Mouse (Predicted Reactivity: Rat)
Applications
ELISA, Dot Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
Phospho-mouse TSC2 (S1343), Antibody; Phospho-mouse TSC2 (S1343) Antibody; Tuberin; Tuberous sclerosis 2 protein homolog; Tsc2; anti-Tsc2 antibody
Host
Rabbit
Reactivity
Mouse (Predicted Reactivity: Rat)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This mouse TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1343 of mouse TSC2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Sequence Length
1814
Applicable Applications for anti-Tsc2 antibody
ELISA, DB (Dot Blot)
Function
In complex with TSC1, this tumor suppressor
inhibits the nutrient-mediated or growth
factor-stimulated phosphorylation of S6K1
and EIF4EBP1 by negatively regulating
mTORC1 signaling. Acts as a
GTPase-activating protein (GAP) for the small
GTPase RHEB, a direct activator of the protein
kinase activity of mTORC1. May also play a
role in microtubule-mediated protein
transport. Also stimulates the intrinsic GTPase
activity of the Ras-related proteins RAP1A
and RAB5.
Cellular Location
Cytoplasm. Membrane; Peripheral membrane
protein. Note=At steady state found in
association with membranes.
Tissue Location
Widely expressed.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
DB (Dot Blot)
(Dot blot analysis of mouse TSC2 Antibody (Phospho S1343) Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.)
DB (Dot Blot)
(Dot blot analysis of mouse TSC2 Antibody (Phospho S1343) Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.)
Related Product Information for anti-Tsc2 antibody
In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth (By similarity).
Product Categories/Family for anti-Tsc2 antibody
NCBI and Uniprot Product Information
Similar Products
Product Notes
The Tsc2 tsc2 (Catalog #AAA288358) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospho-mouse TSC2 (S1343) Antibody reacts with Mouse (Predicted Reactivity: Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's Phospho-mouse TSC2 (S1343) can be used in a range of immunoassay formats including, but not limited to, ELISA, DB (Dot Blot). Researchers should empirically determine the suitability of the Tsc2 tsc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Phospho-mouse TSC2 (S1343), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.