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IHC (Immunohistochemistry)
(PIK3CA/PI3K Alpha Antibody-Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Human PIK3CA/PI3K Alpha Polyclonal Antibody | anti-PIK3CA antibody
PIK3CA/PI3K Alpha Rabbit anti-Human Polyclonal Antibody
Gene Names
PIK3CA; MCM; CWS5; MCAP; PI3K; CLOVE; MCMTC; PI3K-alpha; p110-alpha
Reactivity
Human
Applications
Immunohistochemistry
Purity
Immunoaffinity purified
Synonyms
PIK3CA/PI3K Alpha, Antibody; PIK3CA/PI3K Alpha Rabbit anti-Human Polyclonal Antibody; PathPlus PIK3CA/PI3K Alpha Antibody; PIK3CA; MCAP; p110-alpha; p110alpha; PI3K; PI3-kinase p110 subunit alpha; PI3-kinase subunit alpha; PI3Kalpha; MCM; MCMTC; PI3K-alpha; PtdIns-3-kinase subunit alpha; CLOVE; anti-PIK3CA antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.1% Sodium Azide
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-PIK3CA antibody
IHC (Immunohistochemistry)
Target
Human PIK3CA/PI3K Alpha
Immunogen
LP-10594, synthetic peptide
Conjugation
Unconjugated
Family
Non-Protein Kinase
Preparation and Storage
Aliquot and store undiluted at -20 degree C or below for up to 1 year. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze-thaw cycles.
IHC (Immunohistochemistry)
(PIK3CA/PI3K Alpha Antibody-Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(PIK3CA/PI3K Alpha Antibody-Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemisry)
(PIK3CA/PI3K Alpha Antibody-Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemisry)
(PIK3CA/PI3K Alpha Antibody-Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(PIK3CA/PI3K Alpha Antibody-Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(PIK3CA/PI3K Alpha Antibody-Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(PIK3CA/PI3K Alpha Antibody-Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(PIK3CA/PI3K Alpha Antibody-Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))
Related Product Information for anti-PIK3CA antibody
PI3K Alpha antibody is an unconjugated rabbit polyclonal antibody to PI3K Alpha (PIK3CA) from human. Validated for IHC.
PIK3CA (phosphatidylinositol 3-kinase catalytic subunit, PI3K) is the catalytic subunit of a heterodimeric lipid kinase that is a member of a family that regulates cell growth, transformation, adhesion, apoptosis, survival and motility. Activation of PIK3CA by a growth factor bound receptor tyrosine kinase and downstream production of PIP3 drives pathways that are involved in tumor development and progression in a variety of cancers. PIK3CA kinase is frequently mutated or amplified in cancer, and gene amplifications, deletions and more recently, somatic missense mutations in the PIK3CA gene have been reported in many human cancer types including cancers of the colon, breast, brain, liver, stomach, cervix and lung. Staining is expected to be primarily cytoplasmic but may also localize to cell membranes. PIK3CA is widely expressed in normal tissues.
PIK3CA (phosphatidylinositol 3-kinase catalytic subunit, PI3K) is the catalytic subunit of a heterodimeric lipid kinase that is a member of a family that regulates cell growth, transformation, adhesion, apoptosis, survival and motility. Activation of PIK3CA by a growth factor bound receptor tyrosine kinase and downstream production of PIP3 drives pathways that are involved in tumor development and progression in a variety of cancers. PIK3CA kinase is frequently mutated or amplified in cancer, and gene amplifications, deletions and more recently, somatic missense mutations in the PIK3CA gene have been reported in many human cancer types including cancers of the colon, breast, brain, liver, stomach, cervix and lung. Staining is expected to be primarily cytoplasmic but may also localize to cell membranes. PIK3CA is widely expressed in normal tissues.
References
Br. J. Cancer 2006 94(4):455; Rosty, 2013; Chang, 2016; Xu, 2017; Oncogene 2000 19:2739
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
124,284 Da
NCBI Official Full Name
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
NCBI Official Synonym Full Names
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
NCBI Official Symbol
PIK3CA
NCBI Official Synonym Symbols
MCM; CWS5; MCAP; PI3K; CLOVE; MCMTC; PI3K-alpha; p110-alpha
NCBI Protein Information
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
UniProt Protein Name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
UniProt Gene Name
PIK3CA
UniProt Synonym Gene Names
PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha
UniProt Entry Name
PK3CA_HUMAN
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Product Notes
The PIK3CA pik3ca (Catalog #AAA162942) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PIK3CA/PI3K Alpha Rabbit anti-Human Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PIK3CA/PI3K Alpha can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the PIK3CA pik3ca for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PIK3CA/PI3K Alpha, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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