IHC (Immunohiostchemistry)
(Immunohistochemistry of PION in human brain tissue with PION antibody at 5 ug/mL.)
Rabbit PION Polyclonal Antibody | anti-PION antibody
PION Antibody
Gene Names
GSAP; PION
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
PION, Antibody; PION Antibody; Protein pigeon homolog, gamma-secretase activating protein, GSAP; anti-PION antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
Multiple isoforms of PION are known to exist. PION antibody is predicted to not cross-react with other F-box protein family members.
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
854
Applicable Applications for anti-PION antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a 19 amino acid peptide near the carboxy terminus of human PION.
Target Name
PION
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IHC (Immunohiostchemistry)
(Immunohistochemistry of PION in human brain tissue with PION antibody at 5 ug/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of PION in human brain tissue with PION antibody at 5 ug/mL.)
WB (Western Blot)
(Western blot analysis of PION in EL4 cell lysate with PION antibody at 0.25 ug/mL in (A) the absence and (B) the presence of blocking peptide.)
WB (Western Blot)
(Western blot analysis of PION in EL4 cell lysate with PION antibody at 0.25 ug/mL in (A) the absence and (B) the presence of blocking peptide.)
Related Product Information for anti-PION antibody
Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta amyloid protein precursor (APP) is cleaved by one of two beta secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer's disease patients' brains. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and the APP C-terminal fragment, suggesting that PION may be a potential therapeutic target for the treatment of Alzheimer's disease.
Product Categories/Family for anti-PION antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
28,563 Da
NCBI Official Full Name
gamma-secretase-activating protein
NCBI Official Synonym Full Names
gamma-secretase activating protein
NCBI Official Symbol
GSAP
NCBI Official Synonym Symbols
PION
NCBI Protein Information
gamma-secretase-activating protein
UniProt Protein Name
Gamma-secretase-activating protein
UniProt Gene Name
GSAP
UniProt Synonym Gene Names
PION; GSAP; GSAP-16K
UniProt Entry Name
GSAP_HUMAN
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Product Notes
The PION gsap (Catalog #AAA304447) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PION Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PION can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the PION gsap for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PION, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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