Application Data
Rabbit Plexin A1 (Sema Domain) Polyclonal Antibody | anti-PLXNA1 antibody
Plexin A1 (Sema Domain)
Gene Names
PLXNA1; NOV; NOVP; PLXN1; PLEXIN-A1; DKFZp761P19121
Reactivity
Human, Rat, Mouse
Applications
Immunocytochemistry, Western Blot, ELISA
Purity
Affinity Purified
Synonyms
Plexin A1 (Sema Domain), Antibody; Plexin A1 (Sema Domain); PLXN1; NOV; anti-PLXNA1 antibody
Host
Rabbit
Reactivity
Human, Rat, Mouse
Clonality
Polyclonal
Specificity
The antibody detects a 220 kDa* protein corresponding to the apparent molecular mass of Plexin-A1 on SDS-PAGE immunoblots of adult mouse brain and Cos-7 cells transfected with mouse Plexin-A1. In immunocytochemistry, this antibody co-localizes with anti-Myc in Cos-7 cells transfected with Myc-tagged mouse Plexin-A1.
Purity/Purification
Affinity Purified
Form/Format
Rabbit polyclonal, affinity-purified antibody is supplied in 100 ml phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
Sequence Length
1873
Applicable Applications for anti-PLXNA1 antibody
ICC (Immunocytochemistry), WB (Western Blot), ELISA
Immunogen
Plexin-A1 synthetic peptide (coupled to carrier protein) corresponding to a region within the semaphorin domain in human Plexin-A1. This sequence is highly conserved in rat and mouse Plexin-A1, and has low homology to other Plexin family members.
Preparation and Storage
Store at -20 degree C. Do not aliquot. Stable for 1 year.
Application Data
Application Data
Application Data
Application Data
Related Product Information for anti-PLXNA1 antibody
Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contains a semaphorin domain, multiple glycine-rich motifs, and MET-related sequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites that mediate signal transduction after activation. This region in Plexin-A1 binds the RhoGTPases, Rnd1 and RhoD. Recruitment of Rnd1 has been implicated in the cytoskeletal collapse that occurs after semaphorin-mediated activation of Plexin-A1, while RhoD may block this collapsing activity through interaction with the cytoplasmic region of Plexin-A1. The expression of Plexin-A1, along with the co-receptor Neuropilin-1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3Acontaining regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin-A1 and Neuropilin-1, may have significant roles in axon regeneration after neuronal injury.
References
• Takahashi, T. & Strittmatter, S.M. (2001) Neuron 29:429
• Tamagnone, L. et al. (1999) Cell 99:71.
• Tamagnone, L. et al. (1999) Cell 99:71.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
208419 Da
NCBI Official Full Name
plexin A1
NCBI Official Synonym Full Names
plexin A1
NCBI Official Symbol
PLXNA1
NCBI Official Synonym Symbols
NOV; NOVP; PLXN1; PLEXIN-A1; DKFZp761P19121
NCBI Protein Information
plexin-A1; plexin 1; OTTHUMP00000215966; semaphorin receptor NOV
UniProt Protein Name
cDNA FLJ44113 fis, clone TESTI4046487, highly similar to Mus musculus plexin A1 (Plxna1)
UniProt Entry Name
Q6ZTY7_HUMAN
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Product Notes
The PLXNA1 (Catalog #AAA71529) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Plexin A1 (Sema Domain) reacts with Human, Rat, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Plexin A1 (Sema Domain) can be used in a range of immunoassay formats including, but not limited to, ICC (Immunocytochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the PLXNA1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Plexin A1 (Sema Domain), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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