IHC (Immunohiostchemistry)
(Immunochemical staining of human PPIP5K2 in human liver with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human PPIP5K2 Polyclonal Antibody | anti-PPIP5K2 antibody
Anti-PPIP5K2 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
PPIP5K2, Antibody; Anti-PPIP5K2 Antibody, Rabbit Polyclonal; PPIP5K2 Antibody, Rabbit PAb, Antigen Affinity Purified; Anti-CFAP160 Antibody; Anti-HISPPD1 Antibody; Anti-IP7K2 Antibody; Anti-VIP2 Antibody; anti-PPIP5K2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human PPIP5K2
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-PPIP5K2 antibody
IHC (Immunohistochemistry)
Immunogen
E Coli-derived Human PPIP5K2 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human PPIP5K2 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
IHC (Immunohiostchemistry)
(Immunochemical staining of human PPIP5K2 in human liver with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
IHC (Immunohiostchemistry)
(Immunochemical staining of human PPIP5K2 in human liver with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
IHC (Immunohistochemistry)
(Immunochemical staining of human PPIP5K2 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
IHC (Immunohistochemistry)
(Immunochemical staining of human PPIP5K2 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-PPIP5K2 antibody
The diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) plays critical roles in cell signaling and bioenergetic homeostasis. PPIP5K2 is remarkable for the reversible nature of its kinase activity, its unique ligand-stimulated ATPase activity, and the substrate traveling between two ligand-binding sites. PPIP5K2 mediates cellular phosphate homestasis, since its kinase activity acts as a sensor of extracellular inorganic phosphate levels, dysfunctional PPIP5K2 activity in the inner ear results in hair cell loss and deafness. Mutations in PPIP5K2 gene are associated with hearing loss in human and mouse.
References
Yousaf R, et al. (2018) Mutations in diphosphoinositol-pentakisphosphate kinase ppip5k2 are associated with hearing loss in human and mouse. PLoS Genet 14 (3): e1007297.Wang H, et al. (2014) Synthetic inositol phosphate analogs reveal that ppip5k2 has a surface-mounted substrate capture site that is a target for drug discovery. Chem Biol 21 (5): 689-699.An Y, et al. (2019) Dynamics of substrate processing by ppip5k2, a versatile catalytic machine. Structure 27 (6): 1022-1028.e1022.
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Product Notes
The PPIP5K2 (Catalog #AAA256718) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-PPIP5K2 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PPIP5K2 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the PPIP5K2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PPIP5K2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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