Rabbit anti-Mouse, Rat Prealbumin Polyclonal Antibody | anti-Ttr antibody

Anti-Prealbumin Antibody

Cat. Num. AAA46448

• Gene Names: Ttr; Lr1; Tbpa
• Reactivity: Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunogen Affinity Purified
• Synonyms: Prealbumin, Antibody; Anti-Prealbumin Antibody; Transthyretin; Amyloid polyneuropathy; Amyloidosis I; ATTR; Carpal tunnel syndrome 1; CTS; CTS1; Dysprealbuminemic euthyroidal hyperthyroxinemia; Dystransthyretinemic hyperthyroxinemia; Epididymis luminal protein 111; HEL111; HsT2651; PALB; Prealbumin amyloidosis type I; Prealbumin; Prealbumin Thyroxine-binding; Senile systemic amyloidosis; TBPA; Thyroxine binding prealbumin; TTHY_HUMAN; TTR; TTR protein; transthyretin; anti-Ttr antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: No cross reactivity with other proteins
• Purity/Purification: Immunogen Affinity Purified
• Form/Format: Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05mg NaN₃.
• Sequence Length: 147

• Applicable Applications for anti-Ttr antibody: IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen: E Coli-derived rat Prealbumin recombinant protein (Position: G21-N147). Rat Prealbumin shares 94.5% amino acid (aa) sequence identity with mouse Prealbumin.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Relevant Detrection Systems: The lab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG ( ) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit ( ) for IHC(P)
• Preparation and Storage: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquoted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

WB (Western Blot)

(Anti- Prealbumin Picoband antibody, AAA46448, Western blottingAll lanes: Anti Prealbumin (AAA46448) at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: Mouse Liver Tissue Lysate at 50ugLane 3: Mouse Testis Tissue Lysate at 50ugPredicted bind size: 14KD, 28KD, 55KDObserved bind size: 14KD, 28KD)

IHC (Immunohiostchemistry)

(Anti- Prealbumin Picoband antibody, AAA46448,IHC(P)IHC(P): Rat Kidney Tissue)

IHC (Immunohistochemistry)

(Anti- Prealbumin Picoband antibody, AAA46448,IHC(P)IHC(P): Mouse Pancreas Tissue)

Related Product Information for anti-Ttr antibody

Background: Transthyretin (TTR) is also known as prealbumin. It is mapped to chromosome region 18q11.2-q12.1. This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease.

References

1. Benson, M. D., Dwulet, F. E. Identification of carriers of a variant plasma prealbumin (transthyretin) associated with familial amyloidotic polyneuropathy type I. J. Clin. Invest. 75: 71-75, 1985. 2. Sparkes, R. S., Sasaki, H., Mohandas, T., Yoshioka, K., Klisak, I., Sakaki, Y., Heinzmann, C., Simon, M. I. Assignment of the prealbumin (PALB) gene (familial amyloidotic polyneuropathy) to human chromosome region 18q11.2-q12.1. Hum. Genet. 75: 151-154, 1987.

NCBI and Uniprot Product Information

• NCBI GI #: 333033763
• NCBI GeneID: 24856
• NCBI Accession #: NP_036813.2
• NCBI GenBank Nucleotide #: NM_012681.2
• UniProt Accession #: P02767; Q547K9
• NCBI Official Full Name: transthyretin
• NCBI Official Synonym Full Names: transthyretin
• NCBI Official Symbol: Ttr
• NCBI Official Synonym Symbols: Lr1; Tbpa
• NCBI Protein Information: transthyretin
• UniProt Protein Name: Transthyretin
• UniProt Gene Name: Ttr
• UniProt Synonym Gene Names: Tt
• UniProt Entry Name: TTHY_RAT