Rabbit Presenilin1 Polyclonal Antibody | anti-PSEN1 antibody

Presenilin1 Antibody

Cat. Num. AAA40370

• Gene Names: PSEN1; AD3; FAD; PS1; PS-1; S182
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: Presenilin1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: Presenilin1, Antibody; Presenilin1 Antibody; Presenilin1; AD3; FAD; PS1; PS-1; S182; PSNL1; Presenilin-1; Protein S182; presenilin 1; anti-PSEN1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Presenilin1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 467

• Applicable Applications for anti-PSEN1 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: Presenilin1 antibody was raised against a 23 amino acid synthetic peptide from near the carboxy terminus of human presenilin1.
• Buffer: Presenilin1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Presenilin1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of Presenilin1 in Human Brain cells with Presenilin1 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of Presenilin1 in human brain tissue with Presenilin1 antibody at 2.5 μg/mL.)

WB (Western Blot)

(Western blot analysis of presenilin1 in human brain lysate with presenilin1 antibody at (A) 0.5, (B) 1, and (C) 2 μg/mL.)

Related Product Information for anti-PSEN1 antibody

Presenilin1 Antibody: Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease. Multiple isoforms of presenilin1 are known to exist. This antibody has no cross-reactivity to presenilin2.

NCBI and Uniprot Product Information

• NCBI GI #: 4506163
• NCBI GeneID: 5663
• NCBI Accession #: NP_000012
• NCBI GenBank Nucleotide #: NM_000021.3
• UniProt Accession #: P49768; O95465; Q14762; Q15719; Q15720; Q96P33; Q9UIF0; B2R6D3
• Molecular Weight: 48,997 Da
• NCBI Official Full Name: presenilin-1 isoform I-467
• NCBI Official Synonym Full Names: presenilin 1
• NCBI Official Symbol: PSEN1
• NCBI Official Synonym Symbols: AD3; FAD; PS1; PS-1; S182
• NCBI Protein Information: presenilin-1
• UniProt Protein Name: Presenilin-1
• UniProt Gene Name: PSEN1
• UniProt Synonym Gene Names: AD3; PS1; PSNL1; PS-1; PS1-CTF12
• UniProt Entry Name: PSN1_HUMAN