Rabbit PRICKLE2 Polyclonal Antibody | anti-PRICKLE2 antibody

PRICKLE2 Antibody

Cat. Num. AAA40155

• Gene Names: PRICKLE2; EPM5
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Western Blot, ELISA
• Purity: PRICKLE2 Antibody is affinity chromatography purified via peptide column.
• Synonyms: PRICKLE2, Antibody; PRICKLE2 Antibody; PRICKLE2; EPM5; Prickle-like protein 2; prickle homolog 2; anti-PRICKLE2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Two isoforms of PRICKLE2 are known to exist. PRICKLE2 antibody is predicted to not cross-react with other PRICKLE protein family members.
• Purity/Purification: PRICKLE2 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 844

• Applicable Applications for anti-PRICKLE2 antibody: IF (Immunofluorescence), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: PRICKLE2 antibody was raised against a 15 amino acid synthetic peptide near the center of human PRICKLE2.
• Buffer: PRICKLE2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: PRICKLE2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of PRICKLE2 in rat brain cells with PRICKLE2 antibody at 20 μg/mL.)

WB (Western Blot)

(Western blot analysis of PRICKLE2 in A-20 lysate with PRICKLE2 antibody at 1 μg/mL.)

Related Product Information for anti-PRICKLE2 antibody

PRICKLE2 Antibody: PRICKLE2, also known as Pk2 or EPM5, is a member of a highly conserved protein family that function in the noncanonical WNT signaling pathway which regulates intracellular calcium release and planar cell polarity. Both PRICKLE2 and the related protein PRICKLE1 are expressed in postmitotic neurons and promote neurite outgrowth, and both proteins promote neurite outgrowth via the Dishevelled dependent pathway in C1300 cells. PRICKLE2 localizes to the postsynaptic density and interacts with PSD-95 and NMDA receptors. Defects in the gene encoding PRICKLE2 are associated with autosomal recessive progressive myoclonic epilepsy.

NCBI and Uniprot Product Information

• NCBI GI #: 38524620
• NCBI GeneID: 166336
• NCBI Accession #: NP_942559
• NCBI GenBank Nucleotide #: NM_198859.3
• UniProt Accession #: Q7Z3G6; Q0VF44
• Molecular Weight: 95,615 Da
• NCBI Official Full Name: prickle-like protein 2
• NCBI Official Synonym Full Names: prickle homolog 2 (Drosophila)
• NCBI Official Symbol: PRICKLE2
• NCBI Official Synonym Symbols: EPM5
• NCBI Protein Information: prickle-like protein 2
• UniProt Protein Name: Prickle-like protein 2
• UniProt Gene Name: PRICKLE2
• UniProt Entry Name: PRIC2_HUMAN