IHC (Immunohistochemisry)
(PROC Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PROC Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Human PROC Polyclonal Antibody | anti-PROC antibody
PROC Antibody (Center)
Gene Names
PROC; PC; APC; PROC1; THPH3; THPH4
Reactivity
Human
Applications
Immunohistochemistry, Immunofluorescence, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
PROC, Antibody; PROC Antibody (Center); Vitamin K-dependent protein C; Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV; Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide; PROC; anti-PROC antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This PROC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-206 amino acids from the Central region of human PROC.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.35 (varies by lot)
Sequence Positions
177-206
Sequence Length
516
Applicable Applications for anti-PROC antibody
IHC (Immunohistochemistry), IF (Immunofluorescence), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohistochemisry)
(PROC Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PROC Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohistochemisry)
(PROC Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PROC Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of PROC Antibody (Center) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of PROC Antibody (Center) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
WB (Western Blot)
(PROC Antibody (Center) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the PROC antibody detected the PROC protein (arrow).)
WB (Western Blot)
(PROC Antibody (Center) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the PROC antibody detected the PROC protein (arrow).)
Related Product Information for anti-PROC antibody
This gene encodes a vitamin K-dependent plasma
glycoprotein. The encoded protein is cleaved to its activated form
by the thrombin-thrombomodulin complex. This activated form
contains a serine protease domain and functions in degradation of
the activated forms of coagulation factors V and VIII. Mutations in
this gene have been associated with thrombophilia due to protein C
deficiency, neonatal purpura fulminans, and recurrent venous
thrombosis.
glycoprotein. The encoded protein is cleaved to its activated form
by the thrombin-thrombomodulin complex. This activated form
contains a serine protease domain and functions in degradation of
the activated forms of coagulation factors V and VIII. Mutations in
this gene have been associated with thrombophilia due to protein C
deficiency, neonatal purpura fulminans, and recurrent venous
thrombosis.
Product Categories/Family for anti-PROC antibody
References
Tang, W., et al. Blood (2010) In press :
Agapkina, Iu.V., et al. Mol. Biol. (Mosk.) 44(4):613-619(2010)
Witt, I., et al. Blood Coagul. Fibrinolysis 5(4):651-653(1994)
Zhang, L., et al. Blood 80(4):942-952(1992)
Grundy, C.B., et al. Hum. Genet. 89(6):683-684(1992)
Agapkina, Iu.V., et al. Mol. Biol. (Mosk.) 44(4):613-619(2010)
Witt, I., et al. Blood Coagul. Fibrinolysis 5(4):651-653(1994)
Zhang, L., et al. Blood 80(4):942-952(1992)
Grundy, C.B., et al. Hum. Genet. 89(6):683-684(1992)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
52071
NCBI Official Full Name
vitamin K-dependent protein C preproprotein
NCBI Official Synonym Full Names
protein C (inactivator of coagulation factors Va and VIIIa)
NCBI Official Symbol
PROC
NCBI Official Synonym Symbols
PC; APC; PROC1; THPH3; THPH4
NCBI Protein Information
vitamin K-dependent protein C
UniProt Protein Name
Vitamin K-dependent protein C
UniProt Gene Name
PROC
UniProt Entry Name
PROC_HUMAN
Similar Products
Product Notes
The PROC proc (Catalog #AAA287389) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 177-206. The PROC Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PROC can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), IF (Immunofluorescence), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the PROC proc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PROC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.