Rabbit PSMC5 Polyclonal Antibody | anti-PSMC5 antibody

PSMC5 Antibody

Cat. Num. AAA329555

• Gene Names: PSMC5; S8; p45; SUG1; SUG-1; TBP10; TRIP1; p45/SUG
• Reactivity: Human, Mouse, Rat; Predicted Reactivity: Pig (100%), Zebrafish (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (100%), Xenopus (100%)
• Applications: ELISA, Western Blot
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin
• Synonyms: PSMC5, Antibody; PSMC5 Antibody; 26S protease regulatory subunit 8; 26S proteasome AAA-ATPase subunit RPT6; Cim3; MSUG1 protein; p45; p45/SUG; Proteasome 26S ATPase subunit 5; Proteasome 26S subunit ATPase 5; Proteasome prosome macropain 26S subunit ATPase 5; Proteasome subunit p45; PRS8_HUMAN; PSMC5; Rpt6; S8; SUG1; Tat binding protein homolog 10; TBP10; Thyroid hormone receptor interacting protein 1; Thyroid hormone receptor-interacting protein 1; Thyroid receptor interactor 1; TRIP1; TRIP1 (SUG1); anti-PSMC5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat; Predicted Reactivity: Pig (100%), Zebrafish (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (100%), Xenopus (100%)
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: PSMC5 Antibody detects endogenous levels of total PSMC5.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-PSMC5 antibody: ELISA (Peptide ELISA), WB (Western Blot)
• Immunogen: A synthesized peptide derived from human PSMC5, corresponding to a region within the internal amino acids.
• Conjugation: Unconjugated
• Fragment: Fab fragment
• Subunit Structure: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC5 and few additional components. Component of a complex with USP49 and RUVBL1. Interacts with PRPF19. Interacts with TRIM5. Interacts with NDC80. Interacts with PAAF1. Interacts, in vitro, with the thyroid hormone receptor (in a thyroid hormone T3-dependent manner) and with retinoid X receptor (RXR) (By similarity). Interacts with ERCC6.
• Similarity: Belongs to the AAA ATPase family.
• Subcellular Location: Cytoplasm. Nucleus.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

WB (Western Blot)

(Western blot analysis of extracts from Pc12, using Rpt6 Antibody. The lane on the left was treated with blocking peptide.)

WB (Western Blot)

(Western blot analysis of extracts from 293T, using Rpt6 Antibody. The lane on the left was treated with blocking peptide.)

Related Product Information for anti-PSMC5 antibody

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

NCBI and Uniprot Product Information

• NCBI GI #: 49065819
• NCBI GeneID: 5705
• UniProt Accession #: P62195; O35051; O43208; P47210; P52915; P52916; A8K3Z3; A8K763
• Molecular Weight: 406
• NCBI Official Full Name: 26S protease regulatory subunit 8
• NCBI Official Synonym Full Names: proteasome (prosome, macropain) 26S subunit, ATPase, 5
• NCBI Official Symbol: PSMC5
• NCBI Official Synonym Symbols: S8; p45; SUG1; SUG-1; TBP10; TRIP1; p45/SUG
• NCBI Protein Information: 26S protease regulatory subunit 8; MSUG1 protein; proteasome subunit p45; thyroid receptor interactor 1; Tat-binding protein homolog 10; proteasome 26S ATPase subunit 5; proteasome 26S subunit ATPase 5; 26S proteasome AAA-ATPase subunit RPT6; thyroid horm
• UniProt Protein Name: 26S protease regulatory subunit 8
• UniProt Gene Name: PSMC5
• UniProt Synonym Gene Names: SUG1; TRIP1
• UniProt Entry Name: PRS8_HUMAN