Application Data
(Formalin fixed, paraffin embedded human colon stained with Rabbit anti Human PTK7 (AAA50012) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0))
Rabbit anti-Mouse, Rat PTK7 Polyclonal Antibody | anti-PTK7 antibody
RABBIT ANTI HUMAN PTK7 (N-TERMINAL)
Gene Names
PTK7; CCK4; CCK-4
Reactivity
Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Synonyms
PTK7, Antibody; RABBIT ANTI HUMAN PTK7 (N-TERMINAL); anti-PTK7 antibody
Host
Rabbit
Reactivity
Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
This item recognises human Protein tyrosine kinase-like 7 (PTK7), a member of the receptor tyrosine kinase family, otherwise known as Colon Carcinoma Kinase 4 (CCK4). PTK7 is highly expressed in the kidney, liver, lung, pancreas and melanocytes with weaker expression being detected in the thyroid gland, ovaries, brain, heart and skeletal muscle.
PTK7 may play a role in embryonic development. It is thought to function as a cell adhesion molecule and as a novel regulator of the planar cell polarity (PCP) pathway in vertebrates.
Studies also suggest that PTK7 may be involved in the tumour progression. A loss of PTK7 expression has been observed in melanoma cell lines, whereas increased levels of PTK7 have been detected in high-throughput acute myeloid leukaemia samples. In addition, PTK7 is not expressed in normal colon but has been detected in colon carcinomas and as such is a potential marker for tumour progression.
PTK7 may play a role in embryonic development. It is thought to function as a cell adhesion molecule and as a novel regulator of the planar cell polarity (PCP) pathway in vertebrates.
Studies also suggest that PTK7 may be involved in the tumour progression. A loss of PTK7 expression has been observed in melanoma cell lines, whereas increased levels of PTK7 have been detected in high-throughput acute myeloid leukaemia samples. In addition, PTK7 is not expressed in normal colon but has been detected in colon carcinomas and as such is a potential marker for tumour progression.
Form/Format
Purified
Purified IgG - liquid
Purified IgG - liquid
Concentration
IgG concentration 1.0 mg/ml (varies by lot)
Sequence Length
1078
Applicable Applications for anti-PTK7 antibody
WB (Western Blot), IHC (Immunohistochemistry)
Perservative Stabilisers
0.02% Sodium Azide
Preparation
Preparation
Immunogen
A 15 amino acid peptide located near the N-terminal region of human PTK7.
Buffer Solution
Buffer Solution
Target Species
Human
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Shelf Life: 18 months from date of despatch.
Application Data
(Formalin fixed, paraffin embedded human colon stained with Rabbit anti Human PTK7 (AAA50012) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0))
Application Data
(Formalin fixed, paraffin embedded human colon stained with Rabbit anti Human PTK7 (AAA50012) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0))
Application Data
(Western blot analysis of human (A) mouse (B) and Rat (C) colon lysates probed with Rabbit anti Human PTK7 (AAA50012) at 1ug/ml)
Application Data
(Western blot analysis of human (A) mouse (B) and Rat (C) colon lysates probed with Rabbit anti Human PTK7 (AAA50012) at 1ug/ml)
Related Product Information for anti-PTK7 antibody
MBS222895 recognises human Protein tyrosine kinase-like 7 (PTK7), a member of the receptor tyrosine kinase family, otherwise known as Colon Carcinoma Kinase 4 (CCK4). PTK7 is highly expressed in the kidney, liver, lung, pancreas and melanocytes with weaker expression being detected in the thyroid gland, ovaries, brain, heart and skeletal muscle. PTK7 may play a role in embryonic development. It is thought to function as a cell adhesion molecule and as a novel regulator of the planar cell polarity (PCP) pathway in vertebrates. Studies also suggest that PTK7 may be involved in the tumour progression. A loss of PTK7 expression has been observed in melanoma cell lines, whereas increased levels of PTK7 have been detected in high-throughput acute myeloid leukaemia samples. In addition, PTK7 is not expressed in normal colon but has been detected in colon carcinomas and as such is a potential marker for tumour progression.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
119,197 Da
NCBI Official Full Name
inactive tyrosine-protein kinase 7 isoform e
NCBI Official Synonym Full Names
protein tyrosine kinase 7 (inactive)
NCBI Official Symbol
PTK7
NCBI Official Synonym Symbols
CCK4; CCK-4
NCBI Protein Information
inactive tyrosine-protein kinase 7; PTK7 protein tyrosine kinase 7; colon carcinoma kinase 4; pseudo tyrosine kinase receptor 7; tyrosine-protein kinase-like 7
UniProt Protein Name
Inactive tyrosine-protein kinase 7
UniProt Gene Name
PTK7
UniProt Synonym Gene Names
CCK4; CCK-4
UniProt Entry Name
PTK7_HUMAN
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Product Notes
The PTK7 ptk7 (Catalog #AAA50012) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RABBIT ANTI HUMAN PTK7 (N-TERMINAL) reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PTK7 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the PTK7 ptk7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTK7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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