Rabbit anti-Human PTRF Polyclonal Antibody | anti-PTRF antibody

PTRF Antibody

Cat. Num. AAA40610

• Gene Names: PTRF; CGL4; CAVIN; CAVIN1; FKSG13; cavin-1
• Reactivity: Human
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: PTRF Antibody is affinity chromatography purified via peptide column.
• Synonyms: PTRF, Antibody; PTRF Antibody; PTRF; CGL4; CAVIN; CAVIN1; FKSG13; cavin-1; Polymerase I and transcript release factor; Cavin-1; polymerase I and transcript release factor; anti-PTRF antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: At least three isoforms of PTRF are known to exist; this antibody detects all three isoforms. It is predicted to not cross-react with other members of the cavin family.
• Purity/Purification: PTRF Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 390

• Applicable Applications for anti-PTRF antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: Rabbit polyclonal PTRF antibody was raised against a 19 amino acid peptide near the carboxy terminus of human PTRF.
• Positive Control: Cat. No. MBS151674- Human Spleen Tissue Lysate
• Buffer: PTRF Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: PTRF antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

IF (Immunofluorescence)

(Immunofluorescence of PTRF in human spleen tissue with PTRF antibody at 20 μg/ml.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of PTRF in human spleen tissue with PTRF antibody at 5 μg/ml.)

WB (Western Blot)

(Western blot analysis of PTRF in human spleen tissue lysate with PTRF antibody at (A) 0.5 and (B) 1 μg/mL)

Related Product Information for anti-PTRF antibody

PTRF Antibody: The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts, regulating rRNA transcription by promoting the dissociation of transcription complexes and the re-initiation of polymerase I on nascent rRNA transcripts. PTRF also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins, translocating from caveolae to the cytoplasm after insulin stimulation. PTRF is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.

NCBI and Uniprot Product Information

• NCBI GI #: 42734430
• NCBI GeneID: 284119
• NCBI Accession #: NP_036364
• NCBI GenBank Nucleotide #: NM_012232.5
• UniProt Accession #: Q6NZI2; O00535; Q6GMY1; Q96H74; Q9BT85; Q9HAP4; B2RAW7
• Molecular Weight: 43 kDa
• NCBI Official Full Name: polymerase I and transcript release factor
• NCBI Official Synonym Full Names: polymerase I and transcript release factor
• NCBI Official Symbol: PTRF
• NCBI Official Synonym Symbols: CGL4; CAVIN; CAVIN1; FKSG13; cavin-1
• NCBI Protein Information: polymerase I and transcript release factor; PTRF; TTF-I interacting peptide 12; RNA polymerase I and transcript release factor
• UniProt Protein Name: Polymerase I and transcript release factor
• UniProt Gene Name: PTRF
• UniProt Entry Name: PTRF_HUMAN