IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded Human liver cancer using RAN Polyclonal Antibody at dilution of 1:10)
Rabbit RAN Polyclonal Antibody | anti-RAN antibody
RAN Polyclonal Antibody
Gene Names
RAN; TC4; Gsp1; ARA24
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Antigen affinity purification
Synonyms
RAN, Antibody; RAN Polyclonal Antibody; TC4, Gsp1, ARA24; anti-RAN antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen affinity purification
Concentration
0.5mg/mL (varies by lot)
Sequence Length
216
Applicable Applications for anti-RAN antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen
Synthetic peptide of human RAN
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded Human liver cancer using RAN Polyclonal Antibody at dilution of 1:10)
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded Human liver cancer using RAN Polyclonal Antibody at dilution of 1:10)
WB (Western Blot)
(Western Blot analysis of Hela, NIH/3T3 and HepG2 cell, Mouse testis tissue using RAN Polyclonal Antibody at dilution of 1:200)
WB (Western Blot)
(Western Blot analysis of Hela, NIH/3T3 and HepG2 cell, Mouse testis tissue using RAN Polyclonal Antibody at dilution of 1:200)
Related Product Information for anti-RAN antibody
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
Product Categories/Family for anti-RAN antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
24,423 Da
NCBI Official Full Name
RAN, partial
NCBI Official Synonym Full Names
RAN, member RAS oncogene family
NCBI Official Symbol
RAN
NCBI Official Synonym Symbols
TC4; Gsp1; ARA24
NCBI Protein Information
GTP-binding nuclear protein Ran; GTPase Ran; OK/SW-cl.81; RanGTPase; androgen receptor-associated protein 24; guanosine triphosphatase Ran; member RAS oncogene family; ras-like protein TC4; ras-related nuclear protein
UniProt Protein Name
GTP-binding nuclear protein Ran
UniProt Gene Name
RAN
UniProt Synonym Gene Names
ARA24
UniProt Entry Name
RAN_HUMAN
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Product Notes
The RAN ran (Catalog #AAA169581) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RAN Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's RAN can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the RAN ran for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RAN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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