Rabbit anti-Rat RBP4 Polyclonal Antibody | anti-RBP4 antibody

Anti-RBP4 Antibody, Rabbit Polyclonal

Cat. Num. AAA257286

• Gene Names: Rbp4; RBPA
• Reactivity: Rat
• Applications: Immunohistochemistry, ELISA
• Purity: Protein A & Antigen Affinity
• Synonyms: RBP4, Antibody; Anti-RBP4 Antibody, Rabbit Polyclonal; RBP4 Antibody, Rabbit PAb, Antigen Affinity Purified; retinol binding protein 4, plasma; anti-RBP4 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Rat RBP4
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-RBP4 antibody: IHC (Immunohistochemistry), ELISA
• Immunogen: Recombinant Rat RBP4 protein
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with purified, recombinant Rat RBP4 (rR RBP4). RBP4 specific IgG was purified by Rat RBP4 affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

IHC (Immunohiostchemistry)

(Immunochemical staining of rat RBP4 in rat kidney with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)

IHC (Immunohistochemistry)

(Immunochemical staining of rat RBP4 in rat liver with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)

Related Product Information for anti-RBP4 antibody

Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A), and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex in plasma through their tight interaction. As a member of the lipocalin superfamily, RBP4 containing a beta-barrel structure with a well-defined cavity is secreted from the liver, and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), and this binding is crucial for preventing RBP4 excretion through the kidney glomeruli. RBP4 expressed from an ectopic source efficiently delivers retinol to the eyes, and its deficiency affects night vision largely. Recently, RBP4 as an adipokine, is found to be expressed in adipose tissue and correlated with obesity, insulin resistance (IR) and type 2 diabetes (T2DM).

References

Yang Q, et al. (2005) Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 436(7049): 356-62.Choi SH, et al. (2008) High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus. J Clin Endocrinol Metab. 93(8): 3142-8.Tepper BJ, et al. (2010) Serum retinol-binding protein 4 (RBP4) and retinol in a cohort of borderline obese women with and without gestational diabetes. Clin Biochem. 43(3): 320-3.

NCBI and Uniprot Product Information

• NCBI GI #: 158187535
• NCBI GeneID: 25703
• NCBI Accession #: NP_037294.1
• NCBI GenBank Nucleotide #: NM_013162.1
• Molecular Weight: 23,220 Da
• NCBI Official Full Name: retinol-binding protein 4
• NCBI Official Synonym Full Names: retinol binding protein 4, plasma
• NCBI Official Symbol: Rbp4
• NCBI Official Synonym Symbols: RBPA
• NCBI Protein Information: retinol-binding protein 4; PRBP; plasma retinol-binding protein