Rabbit anti-Human RICK Polyclonal Antibody | anti-RIPK2 antibody

RICK Antibody

Cat. Num. AAA40320

• Gene Names: RIPK2; CCK; RICK; RIP2; CARD3; GIG30; CARDIAK
• Reactivity: Human
• Applications: Immunofluorescence, Immunocytochemistry, Western Blot, ELISA
• Purity: RICK Antibody is affinity chromatography purified via peptide column.
• Synonyms: RICK, Antibody; RICK Antibody; RICK; CCK; RIP2; CARD3; GIG30; CARDIAK; UNQ277/PRO314/PRO34092; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase; receptor-interacting serine-threonine kinase 2; anti-RIPK2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: RICK Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Sequence Length: 540

• Applicable Applications for anti-RIPK2 antibody: IF (Immunofluorescence), ICC (Immunocytochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: RICK antibody was raised against a 15 amino acid peptide near the carboxy terminus of human RICK.
• Buffer: RICK Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: RICK antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of RICK in K562 cells with RICK antibody at 20 μg/mL.)

ICC (Immunocytochemistry)

(Immunocytochemistry of RICK in K562 cells with RICK antibody at 5 μg/mL.)

WB (Western Blot)

(Western blot analysis of RICK in (A) 3T3 and (B) K562 cell lysate with RICK antibody at 0.5 μg/mL)

Related Product Information for anti-RIPK2 antibody

RICK Antibody: Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively. RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF-κB and JNK. RICK interacts with members of the TRAF family, CLARP and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1β. The messenger RNA of RICK is expressed in multiple human tissues.

NCBI and Uniprot Product Information

• NCBI GI #: 20455217
• NCBI GeneID: 8767
• UniProt Accession #: O43353; Q6UWF0; B7Z748
• Molecular Weight: 60 kDa
• NCBI Official Full Name: Receptor-interacting serine/threonine-protein kinase 2
• NCBI Official Synonym Full Names: receptor-interacting serine-threonine kinase 2
• NCBI Official Symbol: RIPK2
• NCBI Official Synonym Symbols: CCK; RICK; RIP2; CARD3; GIG30; CARDIAK
• NCBI Protein Information: receptor-interacting serine/threonine-protein kinase 2; RIP-2; CARD-carrying kinase; growth-inhibiting gene 30; tyrosine-protein kinase RIPK2; receptor-interacting protein 2; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase
• UniProt Protein Name: Receptor-interacting serine/threonine-protein kinase 2
• UniProt Gene Name: RIPK2
• UniProt Synonym Gene Names: CARDIAK; RICK; RIP2; CARD-containing IL-1 beta ICE-kinase; RIP-2
• UniProt Entry Name: RIPK2_HUMAN