Rabbit RIPK1 Polyclonal Antibody | anti-RIPK1 antibody

RIPK1 Antibody

Cat. Num. AAA39236

• Gene Names: RIPK1; RIP; RIP1
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: RIPK1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: RIPK1, Antibody; RIPK1 Antibody; RIPK1; RIP; RIP1; Cell death protein RIP; RIP-1; receptor (TNFRSF)-interacting serine-threonine kinase 1; anti-RIPK1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: RIPK1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 671

• Applicable Applications for anti-RIPK1 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: RIPK1 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human RIPK1.
• Buffer: RIPK1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Positive Control: 1) - Rat Kidney Tissue Lysate
• Preparation and Storage: RIPK1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IHC (Immunohistochemistry)

(Immunohistochemistry of RIPK1 in mouse kidney tissue with RIPK1 antibody at 2.5 μg/ml.)

IF (Immunofluorescence)

(Immunofluorescence of RIPK1 in Mouse Kidney cells with RIPK1 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of RIPK1 in mouse kidney tissue with RIPK1 antibody at 2.5 μg/mL.)

WB (Western Blot)

(Western blot analysis of RIPK1 in rat kidney tissue lysate with RIPK1 antibody at 1 μg/mL.)

Related Product Information for anti-RIPK1 antibody

RIPK1 Antibody: RIPK1 (Receptor Interacting Protein) is a crucial 74 kD adaptor kinase in several of stress-induced signaling pathways and on the crossroad of a cell's decision to live or die. RIPK1 contains an N-terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C-terminal region containing a death domain motif present in the Fas and TNFR1 intracellular domains. Full length RIPK1 is important for signallling to NFκ-B, MAPKs and necrosis, whereas caspase-8 generates a C-terminal RIPK1 cleavage fragment, promoting TNF-induced apoptosis. It is required for TNFRSF1A-mediated and TLR3-induced NF-κB activation. RIPK1-deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age.

NCBI and Uniprot Product Information

• NCBI GI #: 57242761
• NCBI GeneID: 8737
• NCBI Accession #: NP_003795
• NCBI GenBank Nucleotide #: NM_003804.3
• UniProt Accession #: Q13546; Q13180; Q59H33; A0AV89; B2RAG1; B4E3F9
• NCBI Official Full Name: receptor-interacting serine/threonine-protein kinase 1
• NCBI Official Synonym Full Names: receptor (TNFRSF)-interacting serine-threonine kinase 1
• NCBI Official Symbol: RIPK1
• NCBI Official Synonym Symbols: RIP; RIP1
• NCBI Protein Information: receptor-interacting serine/threonine-protein kinase 1; RIP-1; cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; serine/threonine-protein kinase RIP
• UniProt Protein Name: Receptor-interacting serine/threonine-protein kinase 1
• UniProt Gene Name: RIPK1
• UniProt Synonym Gene Names: RIP; RIP1; RIP-1
• UniProt Entry Name: RIPK1_HUMAN