Rabbit anti-Human, Mouse RPS6KA4 Polyclonal Antibody | anti-RPS6KA4 antibody

RPS6KA4 Antibody

Cat. Num. AAA232659

• Gene Names: RPS6KA4; MSK2; RSK-B; S6K-alpha-4
• Reactivity: Human, Mouse
• Applications: Immunofluorescence, Western Blot, ELISA
• Purity: >95%, Protein G purified
• Synonyms: RPS6KA4, Antibody; RPS6KA4 Antibody; Ribosomal protein S6 kinase alpha-4; 90 kDa ribosomal protein S6 kinase 4; Nuclear mitogen- and stress-activated protein kinase 2; Ribosomal protein kinas; RPS6KA4; MSK2; anti-RPS6KA4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 766

• Applicable Applications for anti-RPS6KA4 antibody: IF (Immunofluorescence), WB (Western Blot), ELISA
• Immunogen: Recombinant Human Ribosomal protein S6 kinase alpha-4 protein (237-393AA)
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugation: Non-conjugated
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-82229 / sc-82231 / sc-98524
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

IHC (Immunohistochemisry)

(Immunohistochemistry of paraffin-embedded human gastric cancer using AAA232659 at dilution of 1:100)

IF (Immunofluorescence)

(Immunofluorescent analysis of Hela cells using AAA232659 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

WB (Western Blot)

(Western BlotPositive WB detected in:U251 whole cell lysate,Mouse kidney tissue,Mouse brain tissueAll lanes: RPS6KA4 antibody at 3ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 86,85 kDaObserved band size: 86 kDa)

Related Product Information for anti-RPS6KA4 antibody

Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.

NCBI and Uniprot Product Information

• NCBI GI #: 55743138
• NCBI GeneID: 8986
• NCBI Accession #: NP_001006945.1
• NCBI GenBank Nucleotide #: NM_001006944.1
• UniProt Accession #: O75676; O75585; Q53ES8; A8K7Z8
• Molecular Weight: 84,884 Da
• NCBI Official Full Name: ribosomal protein S6 kinase alpha-4 isoform b
• NCBI Official Synonym Full Names: ribosomal protein S6 kinase A4
• NCBI Official Symbol: RPS6KA4
• NCBI Official Synonym Symbols: MSK2; RSK-B; S6K-alpha-4
• NCBI Protein Information: ribosomal protein S6 kinase alpha-4
• UniProt Protein Name: Ribosomal protein S6 kinase alpha-4
• UniProt Gene Name: RPS6KA4
• UniProt Synonym Gene Names: MSK2; S6K-alpha-4; RSKB
• UniProt Entry Name: KS6A4_HUMAN