Rabbit Ser679/683 FAM129B Polyclonal Antibody | anti-FAM129B antibody

Anti-Phospho-Ser679/683 FAM129B

Cat. Num. AAA72829

• Gene Names: FAM129B; OC58; MEG-3; C9orf88; MINERVA; bA356B19.6
• Reactivity: Human , Mouse (Expected Reactivity: Non-Human primate)
• Applications: Western Blot
• Purity: Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
• Synonyms: Ser679/683 FAM129B, Antibody; Anti-Phospho-Ser679/683 FAM129B; FAM129B (Ser679, 683); anti-FAM129B antibody

• Host: Rabbit
• Reactivity: Human , Mouse (Expected Reactivity: Non-Human primate)
• Clonality: Polyclonal
• Specificity: Specific for the ~83k FAM129B phosphorylated at Ser679/683. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide that was used to generate the antibody but not by the corresponding dephospho-peptide.
• Purity/Purification: Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
• Form/Format: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ?g per ml BSA and 50% glycerol.
• Sequence Length: 733

• Applicable Applications for anti-FAM129B antibody: WB (Western Blot)
• Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser679/683 of human FAM129B, conjugated to keyhole limpet hemocyanin (KLH).
• Preparation and Storage: Store at -20°C; Stable for at least one year.

WB (Western Blot)

(Western blot of 3T3 cell lysate showing specific immunolabeling of the ~83 kDa FAM129B protein phosphorylated at Ser679/683 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is blocked by preadsorption of the phosphopeptide used as the antigen, but not by the corresponding non-phosphopeptide (not shown).)

Related Product Information for anti-FAM129B antibody

Target Description: FAM129B, also known as Niban-like protein 1, belongs to a poorly characterized protein family with unknown category and function. Increased expression of the Niban gene has been observed in renal carcinomas (Adachi et al., 2004; Sun et al., 2007). Suppression of FAM129B expression in HeLa cells has been seen to promote apoptosis, suggesting that it can modulate cell death signaling, and may be involved in the ER stress response (Sun et al., 2007). FAM129B is also up-regulated in various types of thyroid tumors and Hashimoto’s thyroiditis (Matsumoto et al., 2006). It has been suggested that the MAP kinase dependent phosphorylation of FAM129B is important in controlling melanoma cells, as inhibition of B/Raf/MKK/ERK in melanoma cells represses invasion (Old et al., 2009). It is believed that phosphorylated FAM129B not only derepresses invasion, but also regulates events that promote invasion (Old et al., 2009).

NCBI and Uniprot Product Information

• NCBI GI #: 79750824
• NCBI GeneID: 64855
• NCBI Accession #: NP_001030611.1
• NCBI GenBank Nucleotide #: NM_001035534.2
• UniProt Accession #: Q96TA1; Q4LE55; Q5VVW6; Q5VVW7; Q9BUS2; Q9NT35
• Molecular Weight: 83 kDa
• NCBI Official Full Name: niban-like protein 1 isoform 2
• NCBI Official Synonym Full Names: family with sequence similarity 129 member B
• NCBI Official Symbol: FAM129B
• NCBI Official Synonym Symbols: OC58; MEG-3; C9orf88; MINERVA; bA356B19.6
• NCBI Protein Information: niban-like protein 1
• UniProt Protein Name: Niban-like protein 1
• UniProt Gene Name: FAM129B
• UniProt Synonym Gene Names: C9orf88; MINERVA
• UniProt Entry Name: NIBL1_HUMAN