Rabbit SLC4A7 Polyclonal Antibody | anti-SLC4A7 antibody
SLC4A7 Polyclonal Antibody
Gene Names
SLC4A7; NBC2; NBC3; SBC2; NBCN1; SLC4A6
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot
Purity
Affinity Purification
Synonyms
SLC4A7, Antibody; SLC4A7 Polyclonal Antibody; anti-SLC4A7 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
This antibody detects endogenous levels of protein.
Purity/Purification
Affinity Purification
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Concentration
1 mg/ml (varies by lot)
Sequence Length
1090
Applicable Applications for anti-SLC4A7 antibody
ELISA, WB (Western Blot)
Immunogen
Synthesized peptide derived from part region of human protein
Preparation and Storage
Store at -15 degree C to -25 degree C.
Related Product Information for anti-SLC4A7 antibody
Cellular Localization: Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane ; Multi-pass membrane protein . Cell projection, stereocilium . Also described at the apical cell membrane. Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells (By similarity).
Tissue Specificity: Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. Isoform 1 is expressed in skeletal muscle and heart muscle.
Function: Domain:The PDZ-binding motif mediates interaction with the CFTR, SLC9A3R1/EBP50 complex and probably with USH1C.,enzyme regulation:Transporter activity is regulated by CA2/carbonic anhydrase 2, cAMP and PKA. Insensitive to stilbene derivatives. PubMed:10347222 states it is inhibited by 5-(N-ethyl-N-isopropyl)-amiloride (EIPA).,Function:Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity.,PTM:N-glycosylated.,similarity:Belongs to the anion exchanger (TC 2.A.31) family.,subcellular location: Also described at the apical cell membrane. Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells.,subunit:Interacts with CFTR through SLC9A3R1/EBP50. Interacts with USH1C. Forms a complex with ATP6V1B1 and SLC9A3R1/EBP50. Interacts in a pH dependent-manner with CA2/carbonic anhydrase 2.,tissue specificity:Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. Isoform 1 is expressed in skeletal muscle and heart muscle.
Tissue Specificity: Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. Isoform 1 is expressed in skeletal muscle and heart muscle.
Function: Domain:The PDZ-binding motif mediates interaction with the CFTR, SLC9A3R1/EBP50 complex and probably with USH1C.,enzyme regulation:Transporter activity is regulated by CA2/carbonic anhydrase 2, cAMP and PKA. Insensitive to stilbene derivatives. PubMed:10347222 states it is inhibited by 5-(N-ethyl-N-isopropyl)-amiloride (EIPA).,Function:Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity.,PTM:N-glycosylated.,similarity:Belongs to the anion exchanger (TC 2.A.31) family.,subcellular location: Also described at the apical cell membrane. Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells.,subunit:Interacts with CFTR through SLC9A3R1/EBP50. Interacts with USH1C. Forms a complex with ATP6V1B1 and SLC9A3R1/EBP50. Interacts in a pH dependent-manner with CA2/carbonic anhydrase 2.,tissue specificity:Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. Isoform 1 is expressed in skeletal muscle and heart muscle.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
133 kDa (Observed)
NCBI Official Full Name
sodium bicarbonate cotransporter 3 isoform c
NCBI Official Synonym Full Names
solute carrier family 4 member 7
NCBI Official Symbol
SLC4A7
NCBI Official Synonym Symbols
NBC2; NBC3; SBC2; NBCN1; SLC4A6
NCBI Protein Information
sodium bicarbonate cotransporter 3
UniProt Protein Name
Sodium bicarbonate cotransporter 3
UniProt Gene Name
SLC4A7
UniProt Synonym Gene Names
BT; NBC2; NBC2B; NBC3; NBCn1; SBC2; SLC4A6; Bicarbonate transporter
UniProt Entry Name
S4A7_HUMAN
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Product Notes
The SLC4A7 slc4a7 (Catalog #AAA268789) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SLC4A7 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SLC4A7 can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the SLC4A7 slc4a7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC4A7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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