IHC (Immunohiostchemistry)
(SNRPN Antibody (N-term) (AAA287355)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SNRPN Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit SNRPN Polyclonal Antibody | anti-SNRPN antibody
SNRPN Antibody (N-term)
Gene Names
SNRPN; SMN; PWCR; SM-D; sm-N; RT-LI; HCERN3; SNRNP-N; SNURF-SNRPN
Reactivity
Human (Predicted Reactivity: Bovine, Monkey, Mouse, Rat)
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
SNRPN, Antibody; SNRPN Antibody (N-term); Small nuclear ribonucleoprotein-associated protein N; snRNP-N; Sm protein D; Sm-D; Sm protein N; Sm-N; SmN; Tissue-specific-splicing protein; SNRPN; HCERN3; SMN; anti-SNRPN antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Bovine, Monkey, Mouse, Rat)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This SNRPN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-62 amino acids from the N-terminal region of human SNRPN.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
34-62
Sequence Length
244
Applicable Applications for anti-SNRPN antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(SNRPN Antibody (N-term) (AAA287355)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SNRPN Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(SNRPN Antibody (N-term) (AAA287355)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SNRPN Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(SNRPN Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the SNRPN antibody detected the SNRPN protein (arrow).)
WB (Western Blot)
(SNRPN Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the SNRPN antibody detected the SNRPN protein (arrow).)
Related Product Information for anti-SNRPN antibody
The protein encoded by this gene is one polypeptide of a
small nuclear ribonucleoprotein complex and belongs to the snRNP
SMB/SMN family. The protein plays a role in pre-mRNA processing,
possibly tissue-specific alternative splicing events. Although
individual snRNPs are believed to recognize specific nucleic acid
sequences through RNA-RNA base pairing, the specific role of this
family member is unknown. The protein arises from a bicistronic
transcript that also encodes a protein identified as the SNRPN
upstream reading frame (SNURF). Multiple transcription initiation
sites have been identified and extensive alternative splicing
occurs in the 5' untranslated region. Additional splice variants
have been described but sequences for the complete transcripts have
not been determined. The 5' UTR of this gene has been identified as
an imprinting center. Alternative splicing or deletion caused by a
translocation event in this paternally-expressed region is
responsible for Angelman syndrome or Prader-Willi syndrome due to
parental imprint switch failure.
small nuclear ribonucleoprotein complex and belongs to the snRNP
SMB/SMN family. The protein plays a role in pre-mRNA processing,
possibly tissue-specific alternative splicing events. Although
individual snRNPs are believed to recognize specific nucleic acid
sequences through RNA-RNA base pairing, the specific role of this
family member is unknown. The protein arises from a bicistronic
transcript that also encodes a protein identified as the SNRPN
upstream reading frame (SNURF). Multiple transcription initiation
sites have been identified and extensive alternative splicing
occurs in the 5' untranslated region. Additional splice variants
have been described but sequences for the complete transcripts have
not been determined. The 5' UTR of this gene has been identified as
an imprinting center. Alternative splicing or deletion caused by a
translocation event in this paternally-expressed region is
responsible for Angelman syndrome or Prader-Willi syndrome due to
parental imprint switch failure.
Product Categories/Family for anti-SNRPN antibody
References
Benetatos, L., et al. Leuk. Res. 34(2):148-153(2010)
Kim, S.J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (7), 1116-1125 (2008) :
Horsthemke, B., et al. Am. J. Med. Genet. A 146A (16), 2041-2052 (2008) :
Runte, M., et al. Hum. Mol. Genet. 10(23):2687-2700(2001)
Kuslich, C.D., et al. Am. J. Hum. Genet. 64(1):70-76(1999)
Kim, S.J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (7), 1116-1125 (2008) :
Horsthemke, B., et al. Am. J. Med. Genet. A 146A (16), 2041-2052 (2008) :
Runte, M., et al. Hum. Mol. Genet. 10(23):2687-2700(2001)
Kuslich, C.D., et al. Am. J. Hum. Genet. 64(1):70-76(1999)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
24614
NCBI Official Full Name
small nuclear ribonucleoprotein-associated protein N
NCBI Official Synonym Full Names
small nuclear ribonucleoprotein polypeptide N
NCBI Official Symbol
SNRPN
NCBI Official Synonym Symbols
SMN; PWCR; SM-D; sm-N; RT-LI; HCERN3; SNRNP-N; SNURF-SNRPN
NCBI Protein Information
small nuclear ribonucleoprotein-associated protein N
UniProt Protein Name
Small nuclear ribonucleoprotein-associated protein N
UniProt Gene Name
SNRPN
UniProt Synonym Gene Names
HCERN3; SMN; snRNP-N; Sm-D; Sm-N; SmN
UniProt Entry Name
RSMN_HUMAN
Similar Products
Product Notes
The SNRPN snrpn (Catalog #AAA287355) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 34-62. The SNRPN Antibody (N-term) reacts with Human (Predicted Reactivity: Bovine, Monkey, Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's SNRPN can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the SNRPN snrpn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SNRPN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.