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IHC (Immunohistochemistry)
(Anti- SNRPN Picoband antibody, AAA46304, IHC(P)IHC(P): Human Tonsil Tissue)
SNRPN Polyclonal Antibody | anti-SNRPN antibody
Anti-SNRPN Antibody
Gene Names
SNRPN; SMN; PWCR; SM-D; sm-N; RT-LI; HCERN3; SNRNP-N; SNURF-SNRPN
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot
Purity
Immunogen Affinity Purified
Synonyms
SNRPN, Antibody; Anti-SNRPN Antibody; Small nuclear ribonucleoprotein-associated protein N; HCERN3; PWCR; RSMN_HUMAN; RT LI; RTLI; SM D; Sm N; Sm protein D; Sm protein N; Sm-D; Sm-N; Small nuclear ribonucleoprotein associated protein N; Small nuclear ribonucleoprotein polypeptide N; SMD; SmN; SNRNP N; snRNP-N; SNRNPN; SNRPN; SNURF SNRPN; Tissue specific splicing protein; Tissue-specific-splicing protein antibody; small nuclear ribonucleoprotein polypeptide N; anti-SNRPN antibody
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Immunogen Affinity Purified
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Sequence Length
240
Applicable Applications for anti-SNRPN antibody
IHC (Immunohistochemistry), WB (Western Blot)
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human SNRPN (11-39aa QHIDYRMRCILQDGRIFIGTFKAFDKHMN), identical to the related mouse and rat sequences.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
IHC (Immunohistochemistry)
(Anti- SNRPN Picoband antibody, AAA46304, IHC(P)IHC(P): Human Tonsil Tissue)
IHC (Immunohistochemistry)
(Anti- SNRPN Picoband antibody, AAA46304, IHC(P)IHC(P): Human Tonsil Tissue)
IHC (Immunohistochemisry)
(Anti- SNRPN Picoband antibody, AAA46304, IHC(P)IHC(P): Rat Thymus Tissue)
IHC (Immunohistochemisry)
(Anti- SNRPN Picoband antibody, AAA46304, IHC(P)IHC(P): Rat Thymus Tissue)
IHC (Immunohiostchemistry)
(Anti- SNRPN Picoband antibody, AAA46304, IHC(P)IHC(P): Mouse Brain Tissue)
IHC (Immunohiostchemistry)
(Anti- SNRPN Picoband antibody, AAA46304, IHC(P)IHC(P): Mouse Brain Tissue)
WB (Western Blot)
(Anti- SNRPN Picoband antibody, AAA46304, Western blottingAll lanes: Anti SNRPN (AAA46304) at 0.5ug/mlLane 1: Rat Thymus Tissue Lysate at 50ugLane 2: HELA Whole Cell Lysate at 40ugLane 3: HEPG2 Whole Cell Lysate at 40ugLane 4: HEPA Whole Cell Lysate at 40ugPredicted bind size: 25KDObserved bind size: 32KD)
WB (Western Blot)
(Anti- SNRPN Picoband antibody, AAA46304, Western blottingAll lanes: Anti SNRPN (AAA46304) at 0.5ug/mlLane 1: Rat Thymus Tissue Lysate at 50ugLane 2: HELA Whole Cell Lysate at 40ugLane 3: HEPG2 Whole Cell Lysate at 40ugLane 4: HEPA Whole Cell Lysate at 40ugPredicted bind size: 25KDObserved bind size: 32KD)
Related Product Information for anti-SNRPN antibody
Description: Rabbit IgG polyclonal antibody for Small nuclear ribonucleoprotein-associated protein N(SNRPN) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Background: SNRPN(Small Nuclear Ribonucleoprotein Polypeptide N), also called SMN, is a bicistronic imprinted gene that encodes 2 polypeptides, the SmN splicing factor, which is involved in RNA processing, and the SNRPN upstream reading frame (SNURF) polypeptide. The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. SNRPN also encodes a long alternatively spliced transcript containing several small nucleolar RNAs (snoRNAs) and extends downstream to partially overlap the UBE3A gene in the antisense orientation. PWS arises from loss of function of genes in this region expressed exclusively from the paternal chromosome, suggesting that SNRPN may play a role in its etiology. The SNRPN gene is mapped on 15q11.2. Analysis of maternal DNA and of SNRPN cDNA confirmed that the maternal allele is not expressed in fetal brain and heart. Deletions in the transcription unit of the imprinted SNRPN gene occur in patients who have PWS or Angelman syndrome because of a parental imprint switch failure in this chromosomal domain.
Background: SNRPN(Small Nuclear Ribonucleoprotein Polypeptide N), also called SMN, is a bicistronic imprinted gene that encodes 2 polypeptides, the SmN splicing factor, which is involved in RNA processing, and the SNRPN upstream reading frame (SNURF) polypeptide. The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. SNRPN also encodes a long alternatively spliced transcript containing several small nucleolar RNAs (snoRNAs) and extends downstream to partially overlap the UBE3A gene in the antisense orientation. PWS arises from loss of function of genes in this region expressed exclusively from the paternal chromosome, suggesting that SNRPN may play a role in its etiology. The SNRPN gene is mapped on 15q11.2. Analysis of maternal DNA and of SNRPN cDNA confirmed that the maternal allele is not expressed in fetal brain and heart. Deletions in the transcription unit of the imprinted SNRPN gene occur in patients who have PWS or Angelman syndrome because of a parental imprint switch failure in this chromosomal domain.
References
1. Bielinska, B., Blaydes, S. M., Buiting, K., Yang, T., Krajewska-Walasek, M., Horsthemke, B., Brannan, C. I. De novo deletions of SNRPN exon 1 in early human and mouse embryos result in a paternal to maternal imprint switch. Nature Genet. 25: 74-78, 2000. 2. Cattanach, B. M., Barr, J. A., Evans, E. P., Burtenshaw, M., Beechey, C. V., Leff, S. E., Brannan, C. I., Copeland, N. G., Jenkins, N. A., Jones, J. A candidate mouse model for Prader-Willi syndrome which shows an absence of Snrpn expression. Nature Genet. 2: 270-274, 1992. 3. Geuns, E., De Rycke, M., Van Steirteghem, A., Liebaers, I. Methylation imprints of the imprint control region of the SNRPN-gene in human gametes and preimplantation embryos. Hum. Molec. Genet. 12: 2873-2879, 2003.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
25,076 Da
NCBI Official Full Name
small nuclear ribonucleoprotein-associated protein N
NCBI Official Synonym Full Names
small nuclear ribonucleoprotein polypeptide N
NCBI Official Symbol
SNRPN
NCBI Official Synonym Symbols
SMN; PWCR; SM-D; sm-N; RT-LI; HCERN3; SNRNP-N; SNURF-SNRPN
NCBI Protein Information
small nuclear ribonucleoprotein-associated protein N
UniProt Protein Name
Small nuclear ribonucleoprotein-associated protein N
UniProt Gene Name
SNRPN
UniProt Synonym Gene Names
HCERN3; SMN; snRNP-N; Sm-D; Sm-N; SmN
UniProt Entry Name
RSMN_HUMAN
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Product Notes
The SNRPN snrpn (Catalog #AAA46304) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-SNRPN Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SNRPN can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the SNRPN snrpn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SNRPN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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