IHC (Immunohiostchemistry)
(Anti-SOCS3 antibody, AAA44981, IHC(P)IHC(P): Human Tonsil Tissue)
Rabbit SOCS3 Polyclonal Antibody | anti-SOCS3 antibody
Anti-SOCS3 antibody
Gene Names
SOCS3; CIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3
Reactivity
Reactes with: HumanPredict to work with: Mouse
Applications
Immunohistochemistry, Western Blot
Purity
Immunogen affinity purified.
Synonyms
SOCS3, Antibody; Anti-SOCS3 antibody; Suppressor of cytokine signaling 3(SOCS-3); suppressor of cytokine signaling 3; ATOD4 antibody; CIS 3 antibody; CIS-3 antibody; CIS3 antibody; Cish3 antibody; Cytokine induced SH2 protein 3 antibody; Cytokine-inducible SH2 protein 3 antibody; E2a Pbx1 target gene in fibroblasts 10 antibody; EF 10 antibody; MGC71791 antibody; SOCS 3 antibody; SOCS-3 antibody; Socs3 antibody; SOCS3_HUMAN antibody; SSI 3 antibody; SSI-3 antibody; SSI3 antibody; STAT induced STAT inhibitor 3 antibody; STAT-induced STAT inhibitor 3 antibody; Suppressor of cytokine signaling 3 antibody; anti-SOCS3 antibody
Host
Rabbit
Reactivity
Reactes with: Human
Predict to work with: Mouse
Predict to work with: Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
No cross reactivity with other proteins.
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Sequence Length
225
Applicable Applications for anti-SOCS3 antibody
IHC (Immunohistochemistry), WB (Western Blot)
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human SOCS3 (71-85aa RDSSDQRHFFTLSVK), identical to the related mouse sequence, different from the related rat sequence by one amino acid.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
IHC (Immunohiostchemistry)
(Anti-SOCS3 antibody, AAA44981, IHC(P)IHC(P): Human Tonsil Tissue)
IHC (Immunohiostchemistry)
(Anti-SOCS3 antibody, AAA44981, IHC(P)IHC(P): Human Tonsil Tissue)
WB (Western Blot)
(Anti-SOCS3 antibody, AAA44981, Western blottingLane 1: JURKAT Cell LysateLane 2: CEM Cell LysateLane 3: RAJI Cell Lysate)
WB (Western Blot)
(Anti-SOCS3 antibody, AAA44981, Western blottingLane 1: JURKAT Cell LysateLane 2: CEM Cell LysateLane 3: RAJI Cell Lysate)
Related Product Information for anti-SOCS3 antibody
Description: Rabbit IgG polyclonal antibody for Suppressor of cytokine signaling 3(SOCS3) detection. Tested with WB, IHC-P in Human, Mouse.
Background: SOCS3(Suppressor of cytokine signaling 3) is a protein that in humans is encoded by the SOCS3 gene. SOCS3 is transiently expressed by multiple cell lineages within the immune system and functions predominantly as a negative regulator of cytokines that activate the JAK-STAT3 pathway. This gene encodes a member of the STAT-induced STAT inhibitor(SSI), also known as suppressor of cytokine signaling(SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon(IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. For signaling of IL-6, Epo, GCSF and Leptin, binding of SOCS3 to the respective cytokine receptor has been found to be crucial for the inhibitory function of SOCS3. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
Background: SOCS3(Suppressor of cytokine signaling 3) is a protein that in humans is encoded by the SOCS3 gene. SOCS3 is transiently expressed by multiple cell lineages within the immune system and functions predominantly as a negative regulator of cytokines that activate the JAK-STAT3 pathway. This gene encodes a member of the STAT-induced STAT inhibitor(SSI), also known as suppressor of cytokine signaling(SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon(IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. For signaling of IL-6, Epo, GCSF and Leptin, binding of SOCS3 to the respective cytokine receptor has been found to be crucial for the inhibitory function of SOCS3. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
Suppressor of cytokine signaling 3
NCBI Official Synonym Full Names
suppressor of cytokine signaling 3
NCBI Official Symbol
SOCS3
NCBI Official Synonym Symbols
CIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3
NCBI Protein Information
suppressor of cytokine signaling 3; STAT-induced STAT inhibitor 3; cytokine-inducible SH2 protein 3
UniProt Protein Name
Suppressor of cytokine signaling 3
UniProt Gene Name
SOCS3
UniProt Synonym Gene Names
CIS3; SSI3; SOCS-3; CIS-3; SSI-3
UniProt Entry Name
SOCS3_HUMAN
Similar Products
Product Notes
The SOCS3 socs3 (Catalog #AAA44981) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-SOCS3 antibody reacts with Reactes with: Human Predict to work with: Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SOCS3 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the SOCS3 socs3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SOCS3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.