Rabbit SOX10 Polyclonal Antibody | anti-SOX10 antibody

SOX10 Antibody

Cat. Num. AAA40863

• Gene Names: SOX10; DOM; WS4; PCWH; WS2E; WS4C
• Reactivity: Human, Mouse, Rat; Predicted: Pig (100%), Chicken (89%), Goat (100%)
• Applications: Western Blot, ELISA
• Purity: Affinity chromatography purified via peptide column.
• Synonyms: SOX10, Antibody; SOX10 Antibody; SRY (sex determining region Y)-box 10; DOM;WS4; PCWH; WS2E; WS4C; SRY-box 10; anti-SOX10 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat; Predicted: Pig (100%), Chicken (89%), Goat (100%)
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: SOX10 Antibody is predicted to not cross-react with other SOX familiy members.
• Purity/Purification: Affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 466

• Applicable Applications for anti-SOX10 antibody: WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: SOX10 antibody was raised against a peptide corresponding to 18 amino acids near the amino terminus of human SOX10.
• Buffer: SOX10 Antibody is supplied in PBS containing 0.02% sodium azide.
• Species: Human
• Preparation and Storage: Store at 4 degree C for three months and -20 degree C, stable for up to one year.; As with all antibodies care should be taken to avoid repeated freeze thaw cycles; Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of SOX10 in rat heart tissue with SOX10 Antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of SOX10 in rat heart tissue with SOX10 Antibody at 5 μg/mL.)

WB (Western Blot)

(Western blot analysis of SOX10 in rat heart tissue lysate with SOX10 antibody at (A) 1 and (B) 2 μg/mL.)

Related Product Information for anti-SOX10 antibody

SOX10 Antibody: SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and the determination of the cell fate (1). The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins (2). This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development (2). Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschprung disease (3). SLC30A8 expression in beta-cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1beta (4).

Product Categories/Family for anti-SOX10 antibody

Signal Transduction; Stem Cell

References

1. Pusch C, Hustert E, Pfeifer D, et al. The SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor. Hum. Genet. 1998; 103:115-23. 2. Rehberg S, Lischka P, Glaser G, et al. Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation. Mol. Cell Biol. 2002; 22:5826-34. 3. Pingault V, Bondurand N, Kuhlbrodt K, et al. SOX10 mutations in patients with Waardenburg-Hirschprung disease. Nat. Genet. 1998; 18:171-3.

NCBI and Uniprot Product Information

• NCBI GI #: 5902104
• NCBI GeneID: 6663
• NCBI Accession #: NP_008872
• NCBI GenBank Nucleotide #: NM_006941.3
• UniProt Accession #: P56693; Q6FHW7; B4DV62
• Molecular Weight: Predicted: 51 kDa; Observed: 54 kDa
• NCBI Official Full Name: transcription factor SOX-10
• NCBI Official Synonym Full Names: SRY-box 10
• NCBI Official Symbol: SOX10
• NCBI Official Synonym Symbols: DOM; WS4; PCWH; WS2E; WS4C
• NCBI Protein Information: transcription factor SOX-10
• UniProt Protein Name: Transcription factor SOX-10
• UniProt Gene Name: SOX10