Rabbit SPG15 Polyclonal Antibody | anti-ZFYVE26 antibody

SPG15 Antibody

Cat. Num. AAA39857

• Gene Names: ZFYVE26; SPG15; FYVE-CENT
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Western Blot, ELISA
• Purity: SPG15 Antibody is affinity chromatography purified via peptide column.
• Synonyms: SPG15, Antibody; SPG15 Antibody; SPG15; FYVE-CENT; KIAA0321; Zinc finger FYVE domain-containing protein 26; FYVE domain-containing centrosomal protein; zinc finger, FYVE domain containing 26; anti-ZFYVE26 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: SPG15 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 2548

• Applicable Applications for anti-ZFYVE26 antibody: IF (Immunofluorescence), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: SPG15 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human SPG15.
• Buffer: SPG15 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: SPG15 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of SPG15 in Mouse Heart tissue with SPG15 antibody at 20 μg/mL.)

WB (Western Blot)

(Western blot analysis of SPG15 in K562 cell lysate with SPG15 antibody at (A) 1 and (B) 2 μg/mL.)

Related Product Information for anti-ZFYVE26 antibody

SPG15 Antibody: Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders.  Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. SPG15 is the second gene known to be responsible for ARHSP-TCC in the Italian population. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. SPG15 encodes a protein containing a FYVE zinc finger binding domain which is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. SPG15 mRNA is widely distributed in human tissues, as well as in rat embryos, suggesting a possible role for this protein during embryonic development. SPG15 co-localizes partially with endoplasmic reticulum and endosome markers, suggesting a role in intracellular trafficking. Multiple isoforms of SPG15 are known to exist.

NCBI and Uniprot Product Information

• NCBI GI #: 119601358
• NCBI GeneID: 23503
• UniProt Accession #: Q68DK2; O15035; Q68DT9; Q6AW90; Q6ZR50; Q7Z3A4; Q7Z3I1; Q8N4W7; B1B5Y3; B4E2U3
• Molecular Weight: 77,970 Da
• NCBI Official Full Name: zinc finger, FYVE domain containing 26, isoform CRA_a
• NCBI Official Synonym Full Names: zinc finger, FYVE domain containing 26
• NCBI Official Symbol: ZFYVE26
• NCBI Official Synonym Symbols: SPG15; FYVE-CENT
• NCBI Protein Information: zinc finger FYVE domain-containing protein 26; spastizin; FYVE domain-containing centrosomal protein
• UniProt Protein Name: Zinc finger FYVE domain-containing protein 26
• UniProt Gene Name: ZFYVE26
• UniProt Synonym Gene Names: KIAA0321; FYVE-CENT
• UniProt Entry Name: ZFY26_HUMAN