Rabbit SPRYD2 Polyclonal Antibody | anti-CMYA5 antibody

SPRYD2 Antibody

Cat. Num. AAA39801

• Gene Names: CMYA5; SPRYD2; TRIM76; C5orf10
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: SPRYD2 Antibody is affinity chromatography purified via peptide column.
• Synonyms: SPRYD2, Antibody; SPRYD2 Antibody; SPRYD2; TRIM76; C5orf10; DTNBP2; Cardiomyopathy-associated protein 5; Dystrobrevin-binding protein 2; cardiomyopathy associated 5; anti-CMYA5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: SPRYD2 antibody is predicted to not cross-react with other SPRYD protein family members. At least four isoforms of SPRYD2 are known to exist.
• Purity/Purification: SPRYD2 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 4069

• Applicable Applications for anti-CMYA5 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: SPRYD2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human SPRYD2.
• Buffer: SPRYD2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: SPRYD2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of SPRYD2 in mouse brain tissue with SPRYD2 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of SPRYD2 in mouse brain tissue with SPRYD2 antibody at 2.5 μg/mL.)

WB (Western Blot)

(Western blot analysis of SPRYD2 in mouse heart tissue lysate with SPRYD2 antibody at 1 μg/mL.)

Related Product Information for anti-CMYA5 antibody

SPRYD2 Antibody: SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.

NCBI and Uniprot Product Information

• NCBI GI #: 62241003
• NCBI GeneID: 202333
• NCBI Accession #: NP_705838
• NCBI GenBank Nucleotide #: NM_153610.4
• UniProt Accession #: Q8N3K9; Q05CT4; Q2NKX1; Q2T9G9; Q69YQ8; Q69YQ9; Q6P517; Q6P5U3; Q7Z4I1; Q86T34; Q86T49; A0PJB7
• Molecular Weight: 449,211 Da
• NCBI Official Full Name: cardiomyopathy-associated protein 5
• NCBI Official Synonym Full Names: cardiomyopathy associated 5
• NCBI Official Symbol: CMYA5
• NCBI Official Synonym Symbols: SPRYD2; TRIM76; C5orf10
• NCBI Protein Information: cardiomyopathy-associated protein 5; myospryn; genethonin-3; 2310076E16Rik; dystrobrevin-binding protein 2; tripartite motif-containing 76; SPRY domain-containing protein 2; tripartite motif-containing protein 76
• UniProt Protein Name: Cardiomyopathy-associated protein 5
• UniProt Gene Name: CMYA5
• UniProt Synonym Gene Names: C5orf10; DTNBP2; SPRYD2; TRIM76
• UniProt Entry Name: CMYA5_HUMAN