IHC (Immunohiostchemistry)
(Immunohistochemistry of SPT1 in human lung tissue with SPT1 antibody at 5 μg/mL.)
Rabbit anti-Human SPT1 Polyclonal Antibody | anti-SPTLC1 antibody
SPT1 Antibody
Gene Names
SPTLC1; HSN1; LBC1; LCB1; SPT1; SPTI; HSAN1
Reactivity
Human
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
SPT1 Antibody is affinity chromatography purified via peptide column.
Synonyms
SPT1, Antibody; SPT1 Antibody; SPT1; HSN1; LBC1; LCB1; SPTI; HSAN1; Serine palmitoyltransferase 1; Long chain base biosynthesis protein 1; LCB 1; serine palmitoyltransferase, long chain base subunit 1; anti-SPTLC1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
At least two isoforms of SPT1 are known to exist; this antibody will detect only isoform a. SPT1 antibody is predicted to not cross-react with SPT2.
Purity/Purification
SPT1 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
473
Applicable Applications for anti-SPTLC1 antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Conjugate
Unconjugated
Immunogen
SPT1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human SPT1.
Buffer
SPT1 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
SPT1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IHC (Immunohiostchemistry)
(Immunohistochemistry of SPT1 in human lung tissue with SPT1 antibody at 5 μg/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of SPT1 in human lung tissue with SPT1 antibody at 5 μg/mL.)
WB (Western Blot)
(Western blot analysis of SPT1 in (A) A549 and (B) HeLa cell lysate with SPT1 antibody at 1 μg/mL.)
WB (Western Blot)
(Western blot analysis of SPT1 in (A) A549 and (B) HeLa cell lysate with SPT1 antibody at 1 μg/mL.)
Related Product Information for anti-SPTLC1 antibody
SPT1 Antibody: Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. SPT1 is the long chain base subunit 1 of mammalian serine palmitoyltransferase. SPT1 is not catalytically active but is necessary for the stabilization of the SPT2 subunit and anchoring the holoenzyme to the cytosolic face of the endoplasmic reticulum. Missense mutations in this gene have been identified in patients with hereditary sensory neuropathy type 1 (HSAN1). These mutations induce a shift in the substrate specificity of the holoenzyme, leading to the formation and accumulation of two neurotoxic sphingolipids.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
16,073 Da
NCBI Official Full Name
serine palmitoyltransferase 1 isoform a
NCBI Official Synonym Full Names
serine palmitoyltransferase, long chain base subunit 1
NCBI Official Symbol
SPTLC1
NCBI Official Synonym Symbols
HSN1; LBC1; LCB1; SPT1; SPTI; HSAN1
NCBI Protein Information
serine palmitoyltransferase 1; LCB 1; SPT 1; serine C-palmitoyltransferase; serine-palmitoyl-CoA transferase 1; long chain base biosynthesis protein 1
UniProt Protein Name
Serine palmitoyltransferase 1
UniProt Gene Name
SPTLC1
UniProt Synonym Gene Names
LCB1; LCB 1; SPT 1; SPT1
UniProt Entry Name
SPTC1_HUMAN
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Product Notes
The SPTLC1 sptlc1 (Catalog #AAA39861) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SPT1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SPT1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the SPTLC1 sptlc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPT1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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