WB (Western Blot)
(SRD5A2 Antibody (Center) western blot analysis in mouse kidney tissue lysates (15ug/lane).This demonstrates the SRD5A2 antibody detected SRD5A2 protein (arrow).)
Rabbit anti-Human, mouse SRD5A2 Polyclonal Antibody | anti-SRD5A2 antibody
SRD5A2 Antibody (Center)
Reactivity
Human, mouse
Applications
ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
SRD5A2, Antibody; SRD5A2 Antibody (Center); 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha-SR2; SR type 2; Steroid 5-alpha-reductase 2; S5AR 2; Type II 5-alpha reductase; SRD5A2; anti-SRD5A2 antibody
Host
Rabbit
Reactivity
Human, mouse
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This SRD5A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-182 amino acids from the Central region of human SRD5A2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
153-182
Sequence Length
254
Applicable Applications for anti-SRD5A2 antibody
ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Function
Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Cellular Location
Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane;Multi-pass membrane protein
Tissue Location
Expressed in high levels in the prostate and many other androgen-sensitive tissues
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles
WB (Western Blot)
(SRD5A2 Antibody (Center) western blot analysis in mouse kidney tissue lysates (15ug/lane).This demonstrates the SRD5A2 antibody detected SRD5A2 protein (arrow).)
WB (Western Blot)
(SRD5A2 Antibody (Center) western blot analysis in mouse kidney tissue lysates (15ug/lane).This demonstrates the SRD5A2 antibody detected SRD5A2 protein (arrow).)
Related Product Information for anti-SRD5A2 antibody
This gene encodes a microsomal protein expressed at high
levels in androgen-sensitive tissues such as the prostate. The
encoded protein is active at acidic pH and is sensitive to the
4-azasteroid inhibitor finasteride. Deficiencies in this gene can
result in male pseudohermaphroditism, specifically pseudovaginal
perineoscrotal hypospadias (PPSH).
levels in androgen-sensitive tissues such as the prostate. The
encoded protein is active at acidic pH and is sensitive to the
4-azasteroid inhibitor finasteride. Deficiencies in this gene can
result in male pseudohermaphroditism, specifically pseudovaginal
perineoscrotal hypospadias (PPSH).
Product Categories/Family for anti-SRD5A2 antibody
References
Thigpen, A.E., et al. N. Engl. J. Med. 327(17):1216-1219(1992)
Thigpen, A.E., et al. J. Clin. Invest. 90(3):799-809(1992)
Labrie, F., et al. Endocrinology 131(3):1571-1573(1992)
Andersson, S., et al. Nature 354(6349):159-161(1991)
Thigpen, A.E., et al. J. Clin. Invest. 90(3):799-809(1992)
Labrie, F., et al. Endocrinology 131(3):1571-1573(1992)
Andersson, S., et al. Nature 354(6349):159-161(1991)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
28393
NCBI Official Full Name
3-oxo-5-alpha-steroid 4-dehydrogenase 2
NCBI Official Synonym Full Names
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
NCBI Official Symbol
SRD5A2
NCBI Protein Information
3-oxo-5-alpha-steroid 4-dehydrogenase 2
UniProt Protein Name
3-oxo-5-alpha-steroid 4-dehydrogenase 2
UniProt Gene Name
SRD5A2
UniProt Synonym Gene Names
S5AR 2
UniProt Entry Name
S5A2_HUMAN
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Product Notes
The SRD5A2 srd5a2 (Catalog #AAA283940) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 153-182. The SRD5A2 Antibody (Center) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SRD5A2 can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the SRD5A2 srd5a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SRD5A2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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