Rabbit anti-Human, Mouse Stk39 Polyclonal Antibody | anti-STK39 antibody

Stk39 Antibody

Cat. Num. AAA40032

• Gene Names: STK39; DCHT; PASK; SPAK
• Reactivity: Human, Mouse
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: Stk39 Antibody is affinity chromatography purified via peptide column.
• Synonyms: Stk39, Antibody; Stk39 Antibody; Stk39; DCHT; PASK; SPAK; Ste-20-related kinase; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); anti-STK39 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Stk39 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 545

• Applicable Applications for anti-STK39 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: Stk39 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human Stk39.
• Buffer: Stk39 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Stk39 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of stk39 in human brain tissue with stk39 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of Stk39 in human brain tissue with Stk39 antibody at 2.5 μg/mL.)

WB (Western Blot)

(Western blot analysis of Stk39 in SK-N-SH cell lysate with Stk39 antibody at (A) 1 and (B) 2 μg/mL.)

Related Product Information for anti-STK39 antibody

Stk39 Antibody: The serine/threonine kinase Stk39 belongs to the STE20 family, a group of kinases that are known to interact with inflammation-related kinases (such as p38, JNK, NKCC1, PKC-theta, WNK and MLCK), and with transcription factor AP-1. The STE 20 family is involved in diverse biological phenomena, including cell differentiation, cell transformation/ proliferation, cytoskeleton rearrangement, and the regulation of ion transporters. STK39 contains an N-terminal series of proline and alanine repeats (PAPA box), followed by a serine/threonine kinase catalytic domain and is abundantly expressed in the brain. STK39 is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled co-transporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. Recent studies show that STK39 tend to be a novel candidate gene for autism and hypertension.

NCBI and Uniprot Product Information

• NCBI GI #: 115430252
• NCBI GeneID: 27347
• NCBI Accession #: NP_037365
• NCBI GenBank Nucleotide #: NM_013233.2
• UniProt Accession #: Q9UEW8; O14774; Q53S90; Q53SL7; Q53SS1; Q9UER4; X5D9C8
• Molecular Weight: 57,937 Da
• NCBI Official Full Name: STE20/SPS1-related proline-alanine-rich protein kinase
• NCBI Official Synonym Full Names: serine threonine kinase 39
• NCBI Official Symbol: STK39
• NCBI Official Synonym Symbols: DCHT; PASK; SPAK
• NCBI Protein Information: STE20/SPS1-related proline-alanine-rich protein kinase; STE20/SPS1 homolog; ste-20-related kinase; Ste20-like protein kinase; small intestine SPAK-like kinase; serine/threonine-protein kinase 39; proline-alanine-rich STE20-related kinase; serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
• UniProt Protein Name: STE20/SPS1-related proline-alanine-rich protein kinase
• UniProt Gene Name: STK39
• UniProt Synonym Gene Names: SPAK; Ste-20-related kinase
• UniProt Entry Name: STK39_HUMAN