Rabbit anti-Human, Mouse TAB1 Polyclonal Antibody | anti-MAP3K7IP1 antibody

TAB1 Antibody

Cat. Num. AAA40088

• Gene Names: TAB1; 3'-Tab1; MAP3K7IP1
• Reactivity: Human, Mouse
• Applications: Immunofluorescence, Immunocytochemistry, Western Blot, ELISA
• Purity: TAB1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: TAB1, Antibody; TAB1 Antibody; TAB1; 3'-Tab1; MAP3K7IP1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TAK1-binding protein 1; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; anti-MAP3K7IP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: TAB1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 504

• Applicable Applications for anti-MAP3K7IP1 antibody: IF (Immunofluorescence), ICC (Immunocytochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: TAB1 antibody was raised against a synthetic peptide corresponding to 13 amino acids in the center of human TAB1.
• Buffer: TAB1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: TAB1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of TAB1 in 3T3 cells with TAB1 antibody at 2 μg/mL.)

ICC (Immunocytochemistry)

(Immunocytochemistry of TAB1 in K562 cells with TAB1 antibody at 1 μg/mL.)

WB (Western Blot)

(Western blot analysis of TAB1 in 3T3 cell lysate with TAB1 antibody at (A) 0.5, (B) 1, and (C) 2 μg/mL.)

Related Product Information for anti-MAP3K7IP1 antibody

TAB1 Antibody: TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF-beta and members of the Toll-IL-1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF-beta, demonstrating how this protein can function as a mediator between TGF-beta receptors and TAK1.

NCBI and Uniprot Product Information

• NCBI GI #: 5174703
• NCBI GeneID: 10454
• NCBI Accession #: NP_006107
• NCBI GenBank Nucleotide #: NM_006116.2
• UniProt Accession #: Q15750; Q2PP09; Q8IZW2
• Molecular Weight: 49,917 Da
• NCBI Official Full Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha
• NCBI Official Synonym Full Names: TGF-beta activated kinase 1/MAP3K7 binding protein 1
• NCBI Official Symbol: TAB1
• NCBI Official Synonym Symbols: 3'-Tab1; MAP3K7IP1
• NCBI Protein Information: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TAK1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1; mitogen-activated protein kinase kinase kinase 7-interacting protein 1
• UniProt Protein Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
• UniProt Gene Name: TAB1
• UniProt Synonym Gene Names: MAP3K7IP1; TAK1-binding protein 1
• UniProt Entry Name: TAB1_HUMAN