Rabbit anti-Human, Mouse TIGAR Polyclonal Antibody | anti-C12orf5 antibody

TIGAR Antibody

Cat. Num. AAA39787

• Gene Names: C12orf5; FR2BP; TIGAR
• Reactivity: Human, Mouse
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: TIGAR Antibody is affinity chromatography purified via peptide column.
• Synonyms: TIGAR, Antibody; TIGAR Antibody; TIGAR; FR2BP; C12orf5; Fructose-2; 6-bisphosphatase TIGAR; TP53-induced glycolysis and apoptosis regulator; chromosome 12 open reading frame 5; anti-C12orf5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: TIGAR Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 270

• Applicable Applications for anti-C12orf5 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: TIGAR antibody was raised against a 19 amino acid synthetic peptide from near the center of human TIGAR.
• Buffer: TIGAR Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: TIGAR antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of TIGAR in Human Brain cells with TIGAR antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of TIGAR in human brain tissue with TIGAR antibody at 2.5 μg/mL.)

WB (Western Blot)

(Western blot analysis of TIGAR in MCF7 cell lysate with TIGAR antibody at (A) 0.5, (B) 1 and (C) 2 μg/mL.)

Related Product Information for anti-C12orf5 antibody

TIGAR Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. Recent studies have demonstrated the ability of p53 to regulate the expression of several proteins involved in glycolysis and oxidative phosphorylation, such as TIGAR, SCO2, and phosphoglycerate mutase. TIGAR is a recently discovered protein that functions to regulate glycolysis and protect cells against oxidative stress. TIGAR is similar in structure to proteins in the phosphoglycerate mutase family, most notably 6-phosphofructo-2-kinase, suggesting TIGAR may function as a fructose bisphosphatase. Expression of TIGAR in transfected cells correlated with an inhibition of glycolysis and decreased levels of reactive oxygen species and p53-induced apoptosis, indicating that TIGAR may act to modulate the apoptotic response to p53, thereby allowing cells to survive mild or transient stresses.

NCBI and Uniprot Product Information

• NCBI GI #: 9966849
• NCBI GeneID: 57103
• NCBI Accession #: NP_065108
• NCBI GenBank Nucleotide #: NM_020375.2
• UniProt Accession #: Q9NQ88; B2R840
• Molecular Weight: 30,063 Da
• NCBI Official Full Name: fructose-2,6-bisphosphatase TIGAR
• NCBI Official Synonym Full Names: chromosome 12 open reading frame 5
• NCBI Official Symbol: C12orf5
• NCBI Official Synonym Symbols: FR2BP; TIGAR
• NCBI Protein Information: fructose-2,6-bisphosphatase TIGAR; transactivated by NS3TP2 protein; fructose-2,6-bisphosphate 2-phosphatase; probable fructose-2,6-bisphosphatase TIGAR; TP53-induced glycolysis and apoptosis regulator
• UniProt Protein Name: Fructose-2,6-bisphosphatase TIGAR
• UniProt Gene Name: TIGAR
• UniProt Synonym Gene Names: C12orf5
• UniProt Entry Name: TIGAR_HUMAN