Rabbit TLR3 Polyclonal Antibody | anti-TLR3 antibody

TLR3 Antibody

Cat. Num. AAA308306

• Gene Names: TLR3; CD283; IIAE2
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: TLR3, Antibody; TLR3 Antibody; TLR3; CD283; anti-TLR3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total TLR3 protein.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 904

• Applicable Applications for anti-TLR3 antibody: IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human TLR3.
• Target Name: TLR3
• Preparation and Storage: Store at -20 degree C

IHC (Immunohistochemisry)

(Immunohistochemical analysis of paraffin-embedded mouse kidney using TLR3 antibody at dilution of 1:200 (200x lens).)

IHC (Immunohiostchemistry)

(Immunohistochemical analysis of paraffin-embedded human esophageal cancer using TLR3 antibody at dilution of 1:200 (200x lens).)

WB (Western Blot)

(Western blot analysis of extracts from Jurkat cell, using TLR3 antibody.)

Related Product Information for anti-TLR3 antibody

Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses (1-3). TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IkB that normally maintains NF-kB inactivity by sequestering it in the cytoplasm.

Product Categories/Family for anti-TLR3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4507531
• NCBI GeneID: 7098
• NCBI Accession #: NP_003256.1
• NCBI GenBank Nucleotide #: NM_003265.2
• UniProt Accession #: O15455; Q4VAL2; Q504W0; B2RAI7; B7Z7K0; E6Y0F0; E6Y0F1; E9PGH4
• Molecular Weight: 72,937 Da
• NCBI Official Full Name: toll-like receptor 3
• NCBI Official Synonym Full Names: toll-like receptor 3
• NCBI Official Symbol: TLR3
• NCBI Official Synonym Symbols: CD283; IIAE2
• NCBI Protein Information: toll-like receptor 3
• UniProt Protein Name: Toll-like receptor 3
• UniProt Gene Name: TLR3
• UniProt Entry Name: TLR3_HUMAN