IHC (Immunohiostchemistry)
(Immunohistochemistry of TMP21 in human brain tissue with TMP21 antibody at 2.5 ug/mL.)
Rabbit TMP21 Polyclonal Antibody | anti-TMP21 antibody
TMP21 Antibody
Gene Names
TMED10; p23; TMP21; S31I125; Tmp-21-I; S31III125; P24(DELTA)
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
TMP21, Antibody; TMP21 Antibody; Transmembrane emp24 domain-containing protein 10, TMED10; anti-TMP21 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
219
Applicable Applications for anti-TMP21 antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a 19 amino acid peptide from near the carboxy terminus of human TMP21.
Target Name
TMP21
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IHC (Immunohiostchemistry)
(Immunohistochemistry of TMP21 in human brain tissue with TMP21 antibody at 2.5 ug/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of TMP21 in human brain tissue with TMP21 antibody at 2.5 ug/mL.)
WB (Western Blot)
(Western blot analysis of TMP21 in Raji cell lysate with TMP21 antibody at (A) 0.5 and (B) 1 and (C) 2 ug/mL.)
WB (Western Blot)
(Western blot analysis of TMP21 in Raji cell lysate with TMP21 antibody at (A) 0.5 and (B) 1 and (C) 2 ug/mL.)
Related Product Information for anti-TMP21 antibody
TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate gamma-secretase activity.
Product Categories/Family for anti-TMP21 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
24,976 Da
NCBI Official Full Name
TMP21
NCBI Official Synonym Full Names
transmembrane p24 trafficking protein 10
NCBI Official Symbol
TMED10
NCBI Official Synonym Symbols
p23; TMP21; S31I125; Tmp-21-I; S31III125; P24(DELTA)
NCBI Protein Information
transmembrane emp24 domain-containing protein 10
UniProt Protein Name
Transmembrane emp24 domain-containing protein 10
UniProt Gene Name
TMED10
UniProt Synonym Gene Names
TMP21; S31I125; p24delta1
UniProt Entry Name
TMEDA_HUMAN
Similar Products
Product Notes
The TMP21 tmed10 (Catalog #AAA304706) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TMP21 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TMP21 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the TMP21 tmed10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TMP21, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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