IHC (Immunohistochemisry)
(TNFRSF11B Antibody (Center) (AAA287801)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TNFRSF11B Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Human TNFRSF11B Polyclonal Antibody | anti-TNFRSF11B antibody
TNFRSF11B Antibody (Center)
Gene Names
TNFRSF11B; OPG; TR1; OCIF; PDB5
Reactivity
Human
Applications
Immunohistochemistry, Immunofluorescence, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
TNFRSF11B, Antibody; TNFRSF11B Antibody (Center); Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin; TNFRSF11B; OCIF; OPG; anti-TNFRSF11B antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This TNFRSF11B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-271 amino acids from the Central region of human TNFRSF11B.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.42 (varies by lot)
Sequence Positions
243-271
Sequence Length
401
Applicable Applications for anti-TNFRSF11B antibody
IHC (Immunohistochemistry), IF (Immunofluorescence), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohistochemisry)
(TNFRSF11B Antibody (Center) (AAA287801)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TNFRSF11B Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohistochemisry)
(TNFRSF11B Antibody (Center) (AAA287801)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TNFRSF11B Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of TNFRSF11B Antibody (Center) with NCI-H460 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of TNFRSF11B Antibody (Center) with NCI-H460 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
WB (Western Blot)
(TNFRSF11B Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the TNFRSF11B antibody detected the TNFRSF11B protein (arrow).)
WB (Western Blot)
(TNFRSF11B Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the TNFRSF11B antibody detected the TNFRSF11B protein (arrow).)
Related Product Information for anti-TNFRSF11B antibody
The protein encoded by this gene is a member of the
TNF-receptor superfamily. This protein is an osteoblast-secreted
decoy receptor that functions as a negative regulator of bone
resorption. This protein specifically binds to its ligand,
osteoprotegerin ligand, both of which are key extracellular
regulators of osteoclast development. Studies of the mouse
counterpart also suggest that this protein and its ligand play a
role in lymph-node organogenesis and vascular calcification.
Alternatively spliced transcript variants of this gene have been
reported, but their full length nature has not been determined.
TNF-receptor superfamily. This protein is an osteoblast-secreted
decoy receptor that functions as a negative regulator of bone
resorption. This protein specifically binds to its ligand,
osteoprotegerin ligand, both of which are key extracellular
regulators of osteoclast development. Studies of the mouse
counterpart also suggest that this protein and its ligand play a
role in lymph-node organogenesis and vascular calcification.
Alternatively spliced transcript variants of this gene have been
reported, but their full length nature has not been determined.
Product Categories/Family for anti-TNFRSF11B antibody
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Liu, J.M., et al. J. Clin. Endocrinol. Metab. 95 (9), E112-E120 (2010) :
Lieb, W., et al. Arterioscler. Thromb. Vasc. Biol. 30(9):1849-1854(2010)
Paternoster, L., et al. J. Clin. Endocrinol. Metab. 95(8):3940-3948(2010)
Hsu, Y.H., et al. PLoS Genet. 6 (6), E1000977 (2010) :
Liu, J.M., et al. J. Clin. Endocrinol. Metab. 95 (9), E112-E120 (2010) :
Lieb, W., et al. Arterioscler. Thromb. Vasc. Biol. 30(9):1849-1854(2010)
Paternoster, L., et al. J. Clin. Endocrinol. Metab. 95(8):3940-3948(2010)
Hsu, Y.H., et al. PLoS Genet. 6 (6), E1000977 (2010) :
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
46026
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 11B
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 11b
NCBI Official Symbol
TNFRSF11B
NCBI Official Synonym Symbols
OPG; TR1; OCIF; PDB5
NCBI Protein Information
tumor necrosis factor receptor superfamily member 11B
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 11B
UniProt Gene Name
TNFRSF11B
UniProt Synonym Gene Names
OCIF; OPG
UniProt Entry Name
TR11B_HUMAN
Similar Products
Product Notes
The TNFRSF11B tnfrsf11b (Catalog #AAA287801) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 243-271. The TNFRSF11B Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TNFRSF11B can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), IF (Immunofluorescence), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the TNFRSF11B tnfrsf11b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TNFRSF11B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.