Rabbit TOCA-1 Polyclonal Antibody | anti-FNBP1L antibody

TOCA-1 Antibody

Cat. Num. AAA39752

• Gene Names: FNBP1L; TOCA1; C1orf39
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: TOCA-1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: TOCA-1, Antibody; TOCA-1 Antibody; TOCA-1; TOCA1; C1orf39; Formin-binding protein 1-like; Transducer of Cdc42-dependent actin assembly protein 1; Toca-1; formin binding protein 1-like; anti-FNBP1L antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: TOCA-1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 551

• Applicable Applications for anti-FNBP1L antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: TOCA-1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of the human TOCA-1.
• Buffer: TOCA-1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: TOCA-1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of TOCA-1 in Human Brain cells with TOCA-1 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemical staining of human brain tissue using TOCA-1 antibody at 2.5 μg/mL.)

WB (Western Blot)

(Western blot analysis of TOCA-1 in human brain tissue lysate in (A) the absence and (B) the presence of blocking peptide with TOCA-1 antibody at 0.5 μg/mL.)

Related Product Information for anti-FNBP1L antibody

TOCA-1 Antibody: Actin reorganization is important for the regulation of neuronal morphology. A protein involved in this process, the transducer of cdc42-dependent actin assembly 1 (TOCA-1) protein, a member of the evolutionarily conserved pombe CDC15 homology (PCH) protein family, is an essential component of the Cdc42 pathway. TOCA-1 binds both N-WASP and Cdc42 and is essential for Cdc42- and PIP2-induced actin polymerization, suggesting that TOCA-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Decreased expression of TOCA-1 significantly enhances neurite elongation in PC-12 cells; its overexpression in the same cells suppresses neurite elongation. It has been suggested that TOCA-1 negatively regulates axon branching by regulating membrane trafficking by regulating membrane trafficking through the F-BAR/EFC domain. Multiple isoforms of TOCA-1 are known to exist.

NCBI and Uniprot Product Information

• NCBI GI #: 68348709
• NCBI GeneID: 54874
• NCBI Accession #: NP_001020119
• NCBI GenBank Nucleotide #: NM_001024948.2
• UniProt Accession #: Q5T0N5; Q5T0N6; Q6B097; Q6P653; Q6R4Q4; Q9NXG1; J3QSS4
• Molecular Weight: 69,894 Da
• NCBI Official Full Name: formin-binding protein 1-like isoform 1
• NCBI Official Synonym Full Names: formin binding protein 1-like
• NCBI Official Symbol: FNBP1L
• NCBI Official Synonym Symbols: TOCA1; C1orf39
• NCBI Protein Information: formin-binding protein 1-like; toca-1; transducer of Cdc42-dependent actin assembly 1; transducer of Cdc42-dependent actin assembly protein 1
• UniProt Protein Name: Formin-binding protein 1-like
• UniProt Gene Name: FNBP1L
• UniProt Synonym Gene Names: C1orf39; TOCA1; Toca-1
• UniProt Entry Name: FBP1L_HUMAN