Rabbit TRAF6 Polyclonal Antibody | anti-TRAF6 antibody

TRAF6 Antibody

Cat. Num. AAA302687

• Gene Names: TRAF6; RNF85; MGC:3310
• Reactivity: Human, Mouse, Rat
• Applications: Immunocytochemistry, Western Blot, ELISA
• Purity: Ion exchange chromatography purified
• Synonyms: TRAF6, Antibody; TRAF6 Antibody; anti-TRAF6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Ion exchange chromatography purified
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 522

• Applicable Applications for anti-TRAF6 antibody: ICC (Immunocytochemistry), WB (Western Blot), ELISA
• Immunogen Type: Peptide
• Immunogen Description: Raised against a peptide corresponding to 14 amino acids near the C-terminus of human TRAF6.
• Target Name: TRAF6
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ICC (Immunocytochemistry)

(Immunocytochemistry of TRAF6 in K562 cells with TRAF6 antibody at 0.5 ug/mL.)

WB (Western Blot)

(Western blot analysis of TRAF6 in PC-3 cell lysates with TRAF6 antibody at 1 ug/mL in the presence (A) or absence (B) of 1 ug blocking peptide.)

Related Product Information for anti-TRAF6 antibody

Signals from the IL-1 receptor (IL-1R)/Toll-like receptor (TLR) and TNF receptor (TNFR) superfamilies are critical for regulating the function of antigen-presenting cells. Signals transduced by these molecules lead to increased expression and activation of transcription factors such as NF-kB. TNF receptor-associated factor 6 (TRAF6) is unique in that it is a signaling adapter molecule common to both families. TRAF6 is important in cytokine production, dendritic cell (DC) maturation, and the T cell stimulatory capacity of DCs in response to TLR and CD40 ligands. It can be activated in the IL-1R/TLR signaling pathway by IL-1 receptor-associated kinase 1 (IRAK-1) or by other TLR adaptor molecules such as TRIF. Also, it has been shown that TRAF6 can interact directly with TNFR family members CD40 and RANK.

Product Categories/Family for anti-TRAF6 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4759254
• NCBI GeneID: 7189
• NCBI Accession #: NP_004611
• NCBI GenBank Nucleotide #: NM_004620.3
• Molecular Weight: 59,573 Da
• NCBI Official Full Name: TNF receptor-associated factor 6
• NCBI Official Synonym Full Names: TNF receptor-associated factor 6, E3 ubiquitin protein ligase
• NCBI Official Symbol: TRAF6
• NCBI Official Synonym Symbols: RNF85; MGC:3310
• NCBI Protein Information: TNF receptor-associated factor 6
• UniProt Protein Name: TNF receptor-associated factor 6
• UniProt Gene Name: TRAF6
• UniProt Synonym Gene Names: RNF85
• UniProt Entry Name: TRAF6_HUMAN