WB (Western Blot)
Rabbit anti-Human, Mouse TRIM59 Polyclonal Antibody | anti-TRIM59 antibody
TRIM59 Polyclonal Antibody
Gene Names
TRIM59; MRF1; TSBF1; RNF104; TRIM57
Reactivity
Human, Mouse
Applications
ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
Synonyms
TRIM59, Antibody; TRIM59 Polyclonal Antibody; TRIM59; RNF104; TRIM57; TSBF1; Tripartite motif-containing protein 59; RING finger protein 104; Tumor suppressor TSBF-1; anti-TRIM59 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide.
Applicable Applications for anti-TRIM59 antibody
ELISA, IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot)
Function
E3 ubiquitin ligase involved in different processes such as development and immune response (PubMed: , PubMed: ). Serves as a negative regulator for innate immune signaling pathways by suppressing RLR-induced activation of IRF3/7 and NF-kappa-B via interaction with adapter ECSIT (PubMed: ). Regulates autophagy through modulating both the transcription and the ubiquitination of BECN1 (PubMed: ). On the one hand, regulates the transcription of BECN1 through negatively modulating the NF-kappa-B pathway. On the other hand, regulates TRAF6-mediated 'Lys-63'-linked ubiquitination of BECN1, thus affecting the formation of the BECN1-PIK3C3 complex. In addition, mediates 'Lys-48'-linked ubiquitination of TRAF6 and thereby promotes TRAF6 proteasomal degradation (PubMed: ). Acts also as a critical regulator for early embryo development from blastocyst stage to gastrula through modulating F-actin assembly and WASH1 'Lys-63'- linked ubiquitination (By similarity).
Cellular Location
Endoplasmic reticulum membrane; Single-pass membrane protein
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
WB (Western Blot)
WB (Western Blot)
WB (Western Blot)
Related Product Information for anti-TRIM59 antibody
May serve as a multifunctional regulator for innate immune signaling pathways.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
tripartite motif-containing protein 59
NCBI Official Synonym Full Names
tripartite motif containing 59
NCBI Official Symbol
TRIM59
NCBI Official Synonym Symbols
MRF1; TSBF1; RNF104; TRIM57
NCBI Protein Information
tripartite motif-containing protein 59; tumor suppressor TSBF1; RING finger protein 104; tumor suppressor TSBF-1; tripartite motif-containing 57; tripartite motif-containing 59
UniProt Protein Name
Tripartite motif-containing protein 59
UniProt Gene Name
TRIM59
UniProt Synonym Gene Names
RNF104; TRIM57; TSBF1
UniProt Entry Name
TRI59_HUMAN
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Product Notes
The TRIM59 trim59 (Catalog #AAA295949) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TRIM59 Polyclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TRIM59 can be used in a range of immunoassay formats including, but not limited to, ELISA, IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the TRIM59 trim59 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRIM59, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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