WB (Western Blot)
(TRMU Antibody (Center) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the TRMU antibody detected the TRMU protein (arrow).)
Rabbit anti-Human TRMU Polyclonal Antibody | anti-TRMU antibody
TRMU Antibody (Center)
Gene Names
TRMU; MTO2; MTU1; TRMT; TRMT1; TRNT1
Reactivity
Human
Applications
ELISA, Western Blot
Purity
This antibody is purified through a protein A column, followed by peptide affinity purification.
Synonyms
TRMU, Antibody; TRMU Antibody (Center); Mitochondrial tRNA-specific 2-thiouridylase 1; 281-; MTO2 homolog; TRMU; MTU1; TRMT1; anti-TRMU antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
This TRMU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-154 amino acids from the Central region of human TRMU.
Purity/Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Sequence Positions
128-154
Sequence Length
421
Applicable Applications for anti-TRMU antibody
ELISA, WB (Western Blot)
Function
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Cellular Location
Mitochondrion
Tissue Location
Ubiquitous. Abundantly expressed in tissues with high metabolic rates including heart, liver, kidney, and brain
Preparation and Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(TRMU Antibody (Center) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the TRMU antibody detected the TRMU protein (arrow).)
WB (Western Blot)
(TRMU Antibody (Center) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the TRMU antibody detected the TRMU protein (arrow).)
Related Product Information for anti-TRMU antibody
This gene is a member of the trmU family. It encodes a mitochondria-specific tRNA-modifying enzyme that is required for the 2-thio modification of 5-taurinomethyl-2-thiouridine tRNA-Lys on the wobble position of the anticodon.
Product Categories/Family for anti-TRMU antibody
References
Zeharia, A., et al. Am. J. Hum. Genet. 85(3):401-407(2009)
Reiling, E., et al. Eur. J. Hum. Genet. 17(8):1056-1062(2009)
de Moraes, V.C., et al. Biochem. Biophys. Res. Commun. 381(2):210-213(2009)
Otaegui, D., et al. Audiol. Neurootol. 13(5):320-327(2008)
Guan, M.X., et al. Am. J. Hum. Genet. 79(2):291-302(2006)
Reiling, E., et al. Eur. J. Hum. Genet. 17(8):1056-1062(2009)
de Moraes, V.C., et al. Biochem. Biophys. Res. Commun. 381(2):210-213(2009)
Otaegui, D., et al. Audiol. Neurootol. 13(5):320-327(2008)
Guan, M.X., et al. Am. J. Hum. Genet. 79(2):291-302(2006)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
47745
NCBI Official Full Name
mitochondrial tRNA-specific 2-thiouridylase 1 isoform a
NCBI Official Synonym Full Names
tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
NCBI Official Symbol
TRMU
NCBI Official Synonym Symbols
MTO2; MTU1; TRMT; TRMT1; TRNT1
NCBI Protein Information
mitochondrial tRNA-specific 2-thiouridylase 1
UniProt Protein Name
Mitochondrial tRNA-specific 2-thiouridylase 1
UniProt Gene Name
TRMU
UniProt Synonym Gene Names
MTU1; TRMT1
UniProt Entry Name
MTU1_HUMAN
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Product Notes
The TRMU trmu (Catalog #AAA286332) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 128-154. The TRMU Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TRMU can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the TRMU trmu for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRMU, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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