Rabbit TTDN1 Polyclonal Antibody | anti-MPLKIP antibody

TTDN1 Antibody (C-term)

Cat. Num. AAA284702

• Gene Names: MPLKIP; ABHS; TTD4; ORF20; C7orf11
• Reactivity: Human (Predicted Reactivity: Mouse)
• Applications: ELISA, Western Blot
• Purity: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Synonyms: TTDN1, Antibody; TTDN1 Antibody (C-term); M-phase-specific PLK1-interacting protein; TTD non-photosensitive 1 protein; MPLKIP; C7orf11; TTDN1; anti-MPLKIP antibody

• Host: Rabbit
• Reactivity: Human (Predicted Reactivity: Mouse)
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This TTDN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-177 amino acids from the C-terminal region of human TTDN1.
• Purity/Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Sequence Positions: 151-177
• Sequence Length: 179

• Applicable Applications for anti-MPLKIP antibody: ELISA, WB (Western Blot)
• Function: May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.
• Cellular Location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=The subcellular location is regulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome and dispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in M phase
• Tissue Location: Expressed at highest levels in liver and kidney; intermediate expression in skeletal muscle, pancreas, heart and placenta; low expression in brain and lung. Expressed in epidermis and hair follicles.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

WB (Western Blot)

(TTDN1 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the TTDN1 antibody detected the TTDN1 protein (arrow).)

Related Product Information for anti-MPLKIP antibody

The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis.The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy.

References

Zhang, Y., et al. Cell. Mol. Life Sci. 64(5):632-640(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Botta, E., et al. Hum. Mutat. 28(1):92-96(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Nakabayashi, K., et al. Am. J. Hum. Genet. 76(3):510-516(2005)

NCBI and Uniprot Product Information

• NCBI GI #: 20162566
• NCBI GeneID: 136647
• NCBI Accession #: NP_619646.1
• NCBI GenBank Nucleotide #: NM_138701.3
• UniProt Accession #: Q8TAP9
• Molecular Weight: 19147
• NCBI Official Full Name: M-phase-specific PLK1-interacting protein
• NCBI Official Synonym Full Names: M-phase specific PLK1 interacting protein
• NCBI Official Symbol: MPLKIP
• NCBI Official Synonym Symbols: ABHS; TTD4; ORF20; C7orf11
• NCBI Protein Information: M-phase-specific PLK1-interacting protein
• UniProt Protein Name: M-phase-specific PLK1-interacting protein
• UniProt Gene Name: MPLKIP
• UniProt Synonym Gene Names: C7orf11; TTDN1
• UniProt Entry Name: MPLKI_HUMAN