Rabbit TXNIP Polyclonal Antibody | anti-TXNIP antibody

TXNIP Antibody

Cat. Num. AAA40747

• Gene Names: TXNIP; THIF; VDUP1; HHCPA78; EST01027
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, ELISA
• Purity: TXNIP antibody is affinity chromatography purified via peptide column.
• Synonyms: TXNIP, Antibody; TXNIP Antibody; Thioredoxin-interacting protein; BMP and activin membrane-bound inhibitor homolog; non-metastatic gene A protein; NMA; thioredoxin interacting protein; anti-TXNIP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TXNIP antibody is human, mouse and rat reactive.
• Purity/Purification: TXNIP antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 391

• Applicable Applications for anti-TXNIP antibody: WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: TXNIP antibody was raised against a 16 amino acid peptide near the center of human TXNIP
• Buffer: TXNIP antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: TXNIP antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

IF (Immunofluorescence)

(Immunofluorescence of TXNIP in human kidney tissue with TXNIP antibody at 5 μg/ml.Red: TXNIP Antibody (7941)Blue: DAPI staining)

IHC (Immunohiostchemistry)

(Immunohistochemistry of TXNIP in human kidney tissue with TXNIP antibody at 2 μg/ml.)

WB (Western Blot)

(Western blot analysis of TXNIP in C2C12 cell lysate with TXNIP antibody at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide.)

Related Product Information for anti-TXNIP antibody

Thioredoxin-interacting protein (TXNIP) belongs to the arrestin family and plays a critical role in the antioxidant defense mechanisms of hematopoietic cells by activating the p53 pathway during oxidative stress (1,2). It functions as a transcriptional repressor and acts as an oxidative stress mediator by inhibiting thioredoxin activity (2). TXNIP expression is reduced in many types of tumors, and TXNIP overexpression inhibits tumor growth by blocking cell-cycle progression (3). It has recently reported that TXNIP deficiency correlates with a high incidence of hepatocellular carcinoma (HCC) (4). TXNIP and p53 interactions could potentially be a therapeutic target for oxidative stress-related diseases such as hematopoietic malignancies and metabolic diseases (5).

NCBI and Uniprot Product Information

• NCBI GI #: 171184421
• NCBI GeneID: 10628
• NCBI Accession #: NP_006463
• NCBI GenBank Nucleotide #: NM_006472.4
• Molecular Weight: Predicted: 43 kDa; ; Observed: 39 kDa
• NCBI Official Full Name: thioredoxin-interacting protein
• NCBI Official Synonym Full Names: thioredoxin interacting protein
• NCBI Official Symbol: TXNIP
• NCBI Official Synonym Symbols: THIF; VDUP1; HHCPA78; EST01027
• NCBI Protein Information: thioredoxin-interacting protein; thioredoxin binding protein 2; thioredoxin-binding protein 2; vitamin D3 up-regulated protein 1; upregulated by 1,25-dihydroxyvitamin D-3
• UniProt Protein Name: Thioredoxin-interacting protein
• UniProt Gene Name: TXNIP
• UniProt Synonym Gene Names: VDUP1
• UniProt Entry Name: TXNIP_HUMAN