Application Data
(Immunohistological staining of mouse brain with Rabbit anti Human VISA (AAA50064))
Rabbit anti-Mouse, Rat VISA Polyclonal Antibody | anti-VISA antibody
RABBIT ANTI VISA
Gene Names
MAVS; IPS1; VISA; IPS-1; CARDIF
Reactivity
Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Synonyms
VISA, Antibody; RABBIT ANTI VISA; anti-VISA antibody
Host
Rabbit
Reactivity
Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Form/Format
Purified
Purified IgG - liquid
Purified IgG - liquid
Concentration
IgG concentration 1.0mg/ml (varies by lot)
Sequence Length
399
Applicable Applications for anti-VISA antibody
WB (Western Blot), IHC (Immunohistochemistry)
Perservative Stabilisers
0.02% Sodium Azide (NaN3)
Histology Positive Control Tissue
Mouse brain
Buffer Solution
Buffer Solution
Antiserum Preparation
Antisera to human VISA were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
Target Species
Human
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Shelf Life: 18 months from date of despatch.
Application Data
(Immunohistological staining of mouse brain with Rabbit anti Human VISA (AAA50064))
Application Data
(Immunohistological staining of mouse brain with Rabbit anti Human VISA (AAA50064))
Application Data
(Western blot analysis of rat brain lysate probed with Rabbit anti Human VISA (AAA50064) at 0.5(A), 1(B) and 2(C) ug/ml)
Application Data
(Western blot analysis of rat brain lysate probed with Rabbit anti Human VISA (AAA50064) at 0.5(A), 1(B) and 2(C) ug/ml)
Related Product Information for anti-VISA antibody
Rabbit anti VISA antibody recognizes the human Mitochondrial antiviral-signaling protein (MAVS), also known as Virus-induced-signalling-adaptor (VISA), and KIAA1271, VISA is a 540 amino acid outer mitochondrial membrane protein containing a single CARD domain. VISA is an important protein required for innate immune defence against viruses (Huang et al. 2014). VISA acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). VISA is believed to activate the same pathways following detection of extracellular dsRNA by TLR3 and it has been hypothosized that VISA is involved in the regulation of apoptosis following viral infection (Lei et al. 2009). VISA is a ubiquitously expressed protein present in a range of cell types including T-cells, monocytes and epithelial cells, with highest levels in tissues of the heart, skeletal muscle, liver, placenta and in peripheral blood leukocytes. Multiple isoforms of VISA generated by alternative splicing have been identified. Rabbit anti VISA antibody is reactive with full length VISA isoform 1. It does not react with isoforms 2,3,5 or 6, reactivity with isoform 4 is unknown.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
15,012 Da
NCBI Official Full Name
mitochondrial antiviral-signaling protein isoform 2
NCBI Official Synonym Full Names
mitochondrial antiviral signaling protein
NCBI Official Symbol
MAVS
NCBI Official Synonym Symbols
IPS1; VISA; IPS-1; CARDIF
NCBI Protein Information
mitochondrial antiviral-signaling protein; CARD adapter inducing interferon beta; CARD adaptor inducing IFN-beta; IFN-B promoter stimulator 1; interferon beta promoter stimulator protein 1; putative NF-kappa-B-activating protein 031N; virus-induced signaling adaptor; virus-induced-signaling adapter
UniProt Protein Name
Mitochondrial antiviral-signaling protein
UniProt Gene Name
MAVS
UniProt Synonym Gene Names
IPS1; KIAA1271; VISA; MAVS; Cardif; IPS-1; VISA
UniProt Entry Name
MAVS_HUMAN
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Product Notes
The VISA mavs (Catalog #AAA50064) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RABBIT ANTI VISA reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's VISA can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the VISA mavs for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VISA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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