Rabbit anti-Human, Rat VPS16 Polyclonal Antibody | anti-VPS16 antibody

VPS16 Antibody

Cat. Num. AAA233793

• Gene Names: VPS16; hVPS16
• Reactivity: Human, Rat
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: >95%, Protein G purified
• Synonyms: VPS16, Antibody; VPS16 Antibody; Vacuolar protein sorting-associated protein 16 homolog; hVPS16; VPS16; anti-VPS16 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 839

• Applicable Applications for anti-VPS16 antibody: IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Immunogen: Recombinant Human Vacuolar protein sorting-associated protein 16 homolog protein (7-89AA)
• Conjugation: Non-conjugated
• Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

IHC (Immunohistochemisry)

(Immunohistochemistry of paraffin-embedded human brain tissue using AAA233793 at dilution of 1:100)

IHC (Immunohiostchemistry)

(Immunohistochemistry of paraffin-embedded human lung tissue using AAA233793 at dilution of 1:100)

WB (Western Blot)

(Western BlotPositive WB detected in: Rat lung tissueAll lanes: VPS16 antibody at 3ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 95, 79 KDaObserved band size: 95 KDa)

Related Product Information for anti-VPS16 antibody

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for recruitment of VPS33A to the HOPS complex (PubMed:23901104). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS33A but not VPS33B (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770).

Product Categories/Family for anti-VPS16 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 17978479
• NCBI GeneID: 64601
• NCBI Accession #: NP_072097.2
• NCBI GenBank Nucleotide #: NM_022575.3
• UniProt Accession #: Q9H269; Q5JUB1; Q8WU31; Q96EE7; Q96N92; Q9H1Q4; Q9H1Q5
• Molecular Weight: 78,300 Da
• NCBI Official Full Name: vacuolar protein sorting-associated protein 16 homolog isoform 1
• NCBI Official Synonym Full Names: VPS16, CORVET/HOPS core subunit
• NCBI Official Symbol: VPS16
• NCBI Official Synonym Symbols: hVPS16
• NCBI Protein Information: vacuolar protein sorting-associated protein 16 homolog
• UniProt Protein Name: Vacuolar protein sorting-associated protein 16 homolog
• UniProt Gene Name: VPS16
• UniProt Synonym Gene Names: hVPS16