Rabbit VTI1a Polyclonal Antibody | anti-VTI1a antibody

VTI1a Antibody

Cat. Num. AAA40847

• Gene Names: VTI1A; MMDS3; MVti1; VTI1RP2; Vti1-rp2
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Affinity chromatography purified via peptide column.
• Synonyms: VTI1a, Antibody; VTI1a Antibody; Vesicle transport through interaction with t-SNAREs 1A, MMDS3, MVti1, VTI1RP2, Vti1-rp2; anti-VTI1a antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: VTI1a antibody is human, mouse and rat reactive. At least two isoforms of VTI1a are known to exist; this antibody will detect both isoforms. VTI1a antibody is predicted to not cross-react with VTI1b.
• Purity/Purification: Affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 217

• Applicable Applications for anti-VTI1a antibody: IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Immunogen: VTI1a antibody was raised against a 19 amino acid peptide near the center of human VTI1a.
• Buffer: Supplied in PBS containing 0.02% sodium azide.
• Positive Control 1: Human Brain Tissue Lysate
• Conjugate: Unconjugated
• Preparation and Storage: Store at 4 degree C for three months and -20 degree C, stable for up to one year.

IHC (Immunohiostchemistry)

(Immunohistochemistry of VTI1a in human brain tissue with VTI1a antibody at 5 μg/mL.)

WB (Western Blot)

(Western blot analysis of VTI1a in human brain tissue lysate with VTI1a antibody at 1 μg/ml.)

Related Product Information for anti-VTI1a antibody

Vesicle transport through interaction with t-SNAREs homolog 1 (VTI1a and VTI1b) are involved in vesicular transport from the late endosomes to the trans-Golgi network (1). They are both localized in the trans-Golgi network, with VTI1a also found in the Golgi apparatus and VTI1b in endosomes (2,3). VTI1a mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane and promotes fusion of the lipid bilayers (4). VTI1a may be concerned with increased secretion of cytokines associated with cellular senescence (5).

Product Categories/Family for anti-VTI1a antibody

Homeostasis

References

Fischer VM and Stevens TH. A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways. J. Biol. Chem. 1998; 273:2624-30. Kreykenbohm V, Wenzel D, Antonin W et al. The SNAREs vti1a and vti1b have distinct localization and SNARE complex partners. Eur. J. Cell Biol. 2002; 81:273-80. Antonin W, Riedel D, von Mollard GF, et al. The SNARE Vti1a-beta is localized to small synaptic vesicles and participates in a novel SNARE complex. J. Neurosci. 2000; 20:5724-32. Atlashkin V, Kreykenbohm V, Eskelinen EL, et al. Deletion of the SNARE vti1b in mice results in the loss of a single SNARE partner, syntaxin 8. Mol. Cell Biol. 2003; 23:5198-207.

NCBI and Uniprot Product Information

• NCBI GI #: 113374156
• NCBI GeneID: 143187
• NCBI Accession #: NP_660207
• NCBI GenBank Nucleotide #: NM_145206.3
• UniProt Accession #: Q96AJ9; Q5W0D7; A2A307; B4E137
• Molecular Weight: Predicted: 24, 27 kDa; Observed: 26 kDa
• NCBI Official Full Name: vesicle transport through interaction with t-SNAREs homolog 1A isoform b
• NCBI Official Synonym Full Names: vesicle transport through interaction with t-SNAREs 1A
• NCBI Official Symbol: VTI1A
• NCBI Official Synonym Symbols: MMDS3; MVti1; VTI1RP2; Vti1-rp2
• NCBI Protein Information: vesicle transport through interaction with t-SNAREs homolog 1A
• UniProt Protein Name: Vesicle transport through interaction with t-SNAREs homolog 1A
• UniProt Gene Name: VTI1A
• UniProt Entry Name: VTI1A_HUMAN