WB (Western Blot)
(Western Blot of Protein kinase R (PERK) antibody with rat adrenal extracts.Lane 1. Chicken serumLane 2. Tota IgYMW of PERK: 134kDa)
PERK positive control
PERK Positive Control
Gene Names
EIF2AK3; PEK; WRS; PERK
Applications
Western Blot
Synonyms
PERK; N/A; PERK Positive Control; PERK positive control
Form/Format
Western Blot Positive Control in ready to use SDS-sample buffer
Sequence Length
1116
Applicable Applications for PERK positive control
WB (Western Blot)
Immunogen
Purified Protein
Alternative Nomenclature
DKFZp781H1925 antibody; E2AK3_HUMAN antibody; EC 2.7.11.1 antibody; Eif2ak3 antibody; Eukaryotic translation initiation factor 2 alpha kinase 3 antibody; Heme regulated EIF2 alpha kinase antibody; HRI antibody; HsPEK antibody; Pancreatic eIF2 alpha kinase antibody; PEK antibody; PRKR like endoplasmic reticulum kinase antibody; WRS antibody
Preparation and Storage
Store at -20°C for long term storage
WB (Western Blot)
(Western Blot of Protein kinase R (PERK) antibody with rat adrenal extracts.Lane 1. Chicken serumLane 2. Tota IgYMW of PERK: 134kDa)
WB (Western Blot)
(Western Blot of Protein kinase R (PERK) antibody with rat adrenal extracts.Lane 1. Chicken serumLane 2. Tota IgYMW of PERK: 134kDa)
Related Product Information for PERK positive control
Western Blot Positive Control Eukaryotic translation initiation factor 2-alpha kinase 3
Overview: Protein kinase- Eukaryotic translation initiation tactor 2-a kinase 3 (PERK) is a SerinelThreonine protein kinase, type I membrane protein of the endoplasmic reticulum that is abundant in secretory tissues and is inducible by ER-stress. ER stress increases the activity of PERK which phosphorylates the a subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, a reduction of translation initiation and repression of global protein synthesis., which then phosphorylates elF2a to promote reduced translation (1). PERK serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of Cyclin 01. Research studies have demonstrated that PERK-deficient mice have defects in pancreatic 13 cells several weeks after birth, suggesting a role for PERK-mediated translational control in protecting secretory cells from ER stress. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS) which is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities
PERK selective antibodies were generated against a peptide taken from the human PERK protein. The PERK-selective antibodies are affinity purified on an immobilized antigen based affinity matrix, the isolated antibodies were then stabilized in antibody stabilization buffer for long-term storage.
Overview: Protein kinase- Eukaryotic translation initiation tactor 2-a kinase 3 (PERK) is a SerinelThreonine protein kinase, type I membrane protein of the endoplasmic reticulum that is abundant in secretory tissues and is inducible by ER-stress. ER stress increases the activity of PERK which phosphorylates the a subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, a reduction of translation initiation and repression of global protein synthesis., which then phosphorylates elF2a to promote reduced translation (1). PERK serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of Cyclin 01. Research studies have demonstrated that PERK-deficient mice have defects in pancreatic 13 cells several weeks after birth, suggesting a role for PERK-mediated translational control in protecting secretory cells from ER stress. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS) which is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities
PERK selective antibodies were generated against a peptide taken from the human PERK protein. The PERK-selective antibodies are affinity purified on an immobilized antigen based affinity matrix, the isolated antibodies were then stabilized in antibody stabilization buffer for long-term storage.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
134kDa
NCBI Official Full Name
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 2 alpha kinase 3
NCBI Official Symbol
EIF2AK3
NCBI Official Synonym Symbols
PEK; WRS; PERK
NCBI Protein Information
eukaryotic translation initiation factor 2-alpha kinase 3
UniProt Protein Name
Eukaryotic translation initiation factor 2-alpha kinase 3
UniProt Gene Name
EIF2AK3
UniProt Synonym Gene Names
PEK; PERK; HsPEK
UniProt Entry Name
E2AK3_HUMAN
Similar Products
Product Notes
The PERK eif2ak3 (Catalog #AAA75976) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's PERK can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot). Researchers should empirically determine the suitability of the PERK eif2ak3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PERK, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.