Rabbit S100A9 + Calprotectin Antibody | anti-S100A8/S100A9 antibody

S100A9 + Calprotectin (S100A8/A9 Complex)

Cat. Num. AAA215188

• Gene Names: S100A8; P8; MIF; NIF; CAGA; CFAG; CGLA; L1Ag; MRP8; CP-10; MA387; 60B8AG
• Reactivity: Human, Baboon, Monkey, Cow, Pig, Goat, Horse, Cat, Dog, Rabbit, Guinea Pig, Rat, Mouse
• Applications: Immunohistochemistry
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: S100A9 + Calprotectin; N/A; S100A9 + Calprotectin (S100A8/A9 Complex); 60B8AG; Calgranulin A (CAGA); Calgranulin B (CAGB); Calprotectin L1L subunit; Chemotactic cytokine CP-10; Cystic fibrosis antigen (CFAG); Leukocyte L1 complex light chain; L1Ag; Migration inhibitory factor related protein 8; Myeloid-related protein 8 or 14 (MRP8 or MRP14); Myeloid-related protein 14 (MRP14); Neutrophil cytosolic 7kDa protein; NIF; MA387; Pro-inflammatory S100 cytokine; Urinary stone protein band A; anti-S100A8/S100A9 antibody

• Host: Rabbit
• Reactivity: Human, Baboon, Monkey, Cow, Pig, Goat, Horse, Cat, Dog, Rabbit, Guinea Pig, Rat, Mouse
• Isotype: IgG
• Clone Number: MAC3157R
• Specificity: Recognizes the L1 or Calprotectin molecule, an intra-cytoplasmic antigen comprising of a 12kDa alpha chain and a 14kDa beta chain expressed by granulocytes, monocytes and by tissue macrophages. Macrophages usually arise from hematopoietic stem cells in the bone marrow. Under migration into tissues, the monocytes undergo further differentiation to become multifunctional tissue macrophages. They are classified into normal and inflammatory macrophages. Normal macrophages include macrophages in connective tissue (histiocytes), liver (Kupffer's cells), lung (alveolar macrophages), lymph nodes (free and fixed macrophages), spleen (free and fixed macrophages), bone marrow (fixed macrophages), serous fluids (pleural and peritoneal macrophages), skin (histiocytes, Langerhans's cell) and in other tissues. Inflammatory macrophages are present in various exudates. Macrophages are part of the innate immune system, recognizing, engulfing and destroying many potential pathogens including bacteria, pathogenic protozoa, fungi and helminthes. This MAb reacts with neutrophils, monocytes, macrophages, and squamous mucosal epithelia and has been shown as an important marker for identifying macrophages in tissue sections.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 93

• Applicable Applications for anti-S100A8/S100A9 antibody: IHC (Immunohistochemistry)
• Positive Control: Tonsil, lymph node or spleen.
• Immunogen: Affinity Purified monocyte membrane preparation
• Cellular Localization: Cytoplasmic
• Hu-chromosome Location: 1q21
• Antibody Type: Recombinant Rabbit Monoclonal Antibody
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

IHC (Immunohistochemisry)

(Formalin-fixed, paraffin-embedded human Tonsil stained with S100A8/A9 Complex Recombinant Rabbit Monoclonal Antibody (MAC3157R).)

SDS-PAGE

(SDS-PAGE Analysis Purified S100A8/A9 Complex Recombinant Rabbit Monoclonal (MAC3157R). Confirmation of Purity and Integrity of Antibody.)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Tonsil stained with S100A8/A9 Complex Recombinant Rabbit Monoclonal Antibody (MAC3157R).)

References

Flavell DJ, et al. Journal of Histochemistry and Cytochemistry, 1987, 35(11):1217-26.

NCBI and Uniprot Product Information

• NCBI GI #: 47115285
• NCBI GeneID: 6279
• UniProt Accession #: P05109; P06702
• Molecular Weight: 12-14kDa (doublet)
• NCBI Official Full Name: S100A8, partial
• NCBI Official Synonym Full Names: S100 calcium binding protein A8
• NCBI Official Symbol: S100A8
• NCBI Official Synonym Symbols: P8; MIF; NIF; CAGA; CFAG; CGLA; L1Ag; MRP8; CP-10; MA387; 60B8AG
• NCBI Protein Information: protein S100-A8
• UniProt Protein Name: Protein S100-A8
• UniProt Gene Name: S100A8
• UniProt Synonym Gene Names: CAGA; CFAG; MRP8; CFAG; MRP-8; p8
• UniProt Entry Name: S10A8_HUMAN