Syndecan-1/CD138 Recombinant Protein | SDC1 recombinant protein

Syndecan-1/CD138 Protein, Mouse, Recombinant (His Tag)

Cat. Num. AAA258191

• Gene Names: Sdc1; Sstn; Synd; CD138; Synd1; syn-1; AA408134; AA409076
• Purity: >80% as determined by SDS-PAGE
• Synonyms: Syndecan-1/CD138; N/A; Syndecan-1/CD138 Protein, Mouse, Recombinant (His Tag); Mouse Syndecan-1/SDC1/CD138 Protein (His Tag); AA408134 Protein, Mouse; AA409076 Protein, Mouse; CD138 Protein, Mouse; Sstn Protein, Mouse; syn-1 Protein, Mouse; Synd Protein, Mouse; Synd1 Protein, Mouse; syndecan 1; SDC1 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >80% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4, 5 % trehalose 5% mannitol and 0.01% Tween80.

• Source: Mouse
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Gln 17
• Tag: His-Tag
• Molecular Mass: The secreted recombinant mouse SDC1 comprises 246 amino acids and has a calculated molecular mass of 26 kDa. As a result of different glycosylation, the apparent molecular mass of rm SDC1 is approximately 45-60 kDa in SDS-PAGE under reducing conditions.
• Preparation and Storage: Store it under sterile conditions at -20°C to -80°C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage.

SDS-PAGE

Related Product Information for SDC1 recombinant protein

Background: Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.

References

Inki P, et al. (1996) The role of syndecan-1 in malignancies. Ann Med. 28(1): 63-7.Subramanian SV, et al. (1997) Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J Biol Chem. 272(23): 14713-20.Park PW, et al. (2001) Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Nature. 411(6833): 98-102.

NCBI and Uniprot Product Information

• NCBI GI #: 6755438
• NCBI GeneID: 20969
• NCBI Accession #: NP_035649.1
• NCBI GenBank Nucleotide #: NM_011519.2
• UniProt Accession #: P18828; Q62278; Q9WVD2
• NCBI Official Full Name: syndecan-1
• NCBI Official Synonym Full Names: syndecan 1
• NCBI Official Symbol: Sdc1
• NCBI Official Synonym Symbols: Sstn; Synd; CD138; Synd1; syn-1; AA408134; AA409076
• NCBI Protein Information: syndecan-1
• UniProt Protein Name: Syndecan-1
• UniProt Gene Name: Sdc1
• UniProt Synonym Gene Names: Synd-1; Synd1; SYND1