Purity Info
PDE9A active protein
PDE9A, Active
Gene Names
PDE9A; HSPDE9A2
Purity
>90%
Synonyms
PDE9A; N/A; PDE9A, Active; PDE9A active protein
Host
Sf9 cells
Purity/Purification
>90%
Form/Format
50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Concentration
0.1 ug/ml (varies by lot)
Specific Activity
60 nmol/min/mg
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Shipping: Dry Ice
Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Purity Info
Purity Info
Specific Activity
Specific Activity
Related Product Information for PDE9A active protein
Description: Full-length recombinant human PDE9A was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Scientific Background: PDE9A is a member of the phosphodiesterase (PDE) family that catalyzes the hydrolysis of cGMP to the monophosphate and thus plays an important role in signal transduction by regulating the intracellular concentration of cyclic nucleotides (1). Multiple transcript variants encoding several different isoforms have been found for PDE9A (2). These mRNAs differ in the use of specific combinations of exons located at the 5' end of the gene while the 3' half, encoding the catalytic domain of the protein, always has the same combination of exons. PDE9A has been used in the study of gene- disease association, gene-environment interaction, and pharmacogenomic/toxicogenomic. PDE9A is mainly expressed in spleen, small intestine, and brain.
Scientific Background: PDE9A is a member of the phosphodiesterase (PDE) family that catalyzes the hydrolysis of cGMP to the monophosphate and thus plays an important role in signal transduction by regulating the intracellular concentration of cyclic nucleotides (1). Multiple transcript variants encoding several different isoforms have been found for PDE9A (2). These mRNAs differ in the use of specific combinations of exons located at the 5' end of the gene while the 3' half, encoding the catalytic domain of the protein, always has the same combination of exons. PDE9A has been used in the study of gene- disease association, gene-environment interaction, and pharmacogenomic/toxicogenomic. PDE9A is mainly expressed in spleen, small intestine, and brain.
Product Categories/Family for PDE9A active protein
References
1. Fisher, D A. et al: Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase. J. Biol. Chem. 273: 15559-15564, 1998. 2. Soderling, S H. et al: Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J. Biol. Chem. 273: 15553-15558, 1998.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
~86 kDa
NCBI Official Full Name
Homo sapiens phosphodiesterase 9A (PDE9A), transcript variant 2, mRNA
NCBI Official Synonym Full Names
phosphodiesterase 9A
NCBI Official Symbol
PDE9A
NCBI Official Synonym Symbols
HSPDE9A2
NCBI Protein Information
high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
UniProt Protein Name
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
UniProt Gene Name
PDE9A
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Product Notes
The PDE9A pde9a (Catalog #AAA73107) is an Active Protein produced from Sf9 cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PDE9A, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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